22 clinical trials found.
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A MULTI-CENTER OPEN LABEL PHASE 1/2 STUDY OF CYT-0851 AN ORAL RAD51 INHIBITOR IN PATIENTS WITH RELAPSED/REFRACTORY B-CELL MALIGNANCIES AND ADVANCED SOLID TUMORS
The purpose of the study to determine the safety of CYT-0851 in patients with relapsed/refractory B-Cell malignancies and advanced solid tumors. The study drug ...Phase
Interventional
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Site for EA1181 (CompassHER2-pCR): Preoperative THP and postoperative HP in patients who achieve a pathologic complete response
The purpose of the study is to determine the safety and tolerability of pre-operative therapy with 12 weeks of taxane, trastuzumab (or FDA approved biosimilar ...Phase
Interventional
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First-in-human open-label dose-escalation trial with expansion cohorts to evaluate safety of GEN1046 in subjects with malignant solid tumors
The purpose of the study is to determine the safety of GEN1046 in patients with malignant solid tumors. GEN1046 is investigational drug in this study ...Phase
Interventional
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A Phase 1 Multicenter Open-label Dose-Exploration and Dose-Expansion Study Evaluating the Safety Tolerability Pharmacokinetics and Efficacy of AMG 650 in Subjects With Advanced Solid Tumors
The purpose of this study is to obtain initial information on the safety and tolerability (good or bad effects) of a drug given by mouth ...Phase
Interventional
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A Multicenter Phase I/II Trial of Anastrozole Palbociclib Trastuzumab and Pertuzumab in HR-positive Her2-positive Metastatic Breast Cancer (ASPIRE)
The purpose of this study is to assess the safety and effectiveness of giving anastrozole, palbociclib, trastuzumab and pertuzumab to women with hormone receptor (HR ...Phase
Interventional
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RT CHARM: PHASE III RANDOMIZED TRIAL OF HYPOFRACTIONATED POST MASTECTOMY RADIATION WITH BREAST RECONSTRUCTION (ALLIANCE A221505)
The primary rationale for accelerated PMRT is the enhanced convenience for patients, which may result in increased access to PMRT. With data now available documenting ...Phase
Interventional
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Radiation Dermatitis: A phase 1 randomized double blinded placebo controlled study of the safety and efficacy of a caffeine-based antifibrosis cream in patients with breast cancer undergoing radiation therapy (ReDCoAT Study)
The purpose of the study is to evaluate whether a caffeine-based cream can reduce the rates of complications in patients with tissue expander based reconstruction ...Phase
Interventional
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A Phase 1/1b Open-Label Multi-Center Study to Characterize the Safety and Tolerability of TRQ15-01 in Patients with Relapsed/Refractory Solid Tumors and Lymphomas
The purpose of this study is to characterize the safety, tolerability, pharmacokinetics, pharmacodynamics and antitumor activity of TRQ15-01 administered i.v. in patients with relapsed ...Phase
Interventional
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A phase III multicenter randomized open-label trial to evaluate efficacy and safety of ribociclib with endocrine therapy as an adjuvant treatment in patients with hormone receptor-positive HER2-negative early breast cancer (New Adjuvant TriAl with Ribociclib [LEE011]: NATALEE).
The purpose of the trial is to evaluate the efficacy and the safety of ribociclib when given in combination with endocrine (hormonal) therapy, compared to ...Phase
Interventional
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A Phase 1/2 Study of Oral LOXO-292 in Patients With Advanced Solid Tumors Including RET Fusion-Positive Solid Tumors Medullary Thyroid Cancer and Other Tumors With RET Activation (LIBRETTO-001)
The purpose of this research study is to determine the safety of an investigational treatment called LOXO-292. LOXO-292 is an oral investigational drug that may ...Phase
Interventional
