8 clinical trials found.
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A Phase I/II Study of M3814 and Avelumab in Combination with Hypofractionated Radiation in Patients with Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies
The purpose of the study is to determine if M3814 in combination with radiation therapy and avelumab is safe and tolerable in patients with advanced ...Phase
Interventional
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Randomized Double-Blind Phase III Trial of Vitamin D3 Supplementation in Patients with Previously Untreated Metastatic Colorectal Cancer (SOLARIS)
The purpose of the study is to determine the efficacy and safety of how well vitamin D3 given with standard chemotherapy and bevacizumab works in ...Phase
Interventional
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Phase 1/2 Trial of MRTX849 in Combination with TNO155 in Patients with Advanced Solid Tumors with KRAS G12C Mutation
This study will evaluate if patients with cancer with a KRAS G12C mutation will benefit from treatment with MRTX849 and TNO155. It will also look ...Phase
Interventional
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A PHASE II RANDOMIZED CONTROLLED TRIAL OF NIVOLUMAB IN COMBINATION WITH BMS-986253 OR CABIRALIZUMAB IN ADVANCED HEPATOCELLULAR CARCINOMA (HCC) PATIENTS
The purpose of this research study is to determine whether treatment with Cabiralizumab or HuMax-IL8 in combination with Nivolumab has additional benefit to Nivolumab treatment ...Phase
Interventional
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A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C Mutation
The purpose of this study is to test the safety, tolerability, and effectiveness of MRTX849 (called “the study drug” from now on) for advanced cancers ...Phase
Interventional
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A Phase 1/2 Study of Oral LOXO-292 in Patients With Advanced Solid Tumors Including RET Fusion-Positive Solid Tumors Medullary Thyroid Cancer and Other Tumors With RET Activation (LIBRETTO-001)
The purpose of this research study is to determine the safety of an investigational treatment called LOXO-292. LOXO-292 is an oral investigational drug that may ...Phase
Interventional
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Randomized Trial of Standard Chemotherapy Alone or Combined with Atezolizumab as Adjuvant Therapy for Patients with Stage III Colon Cancer and Deficient DNA Mismatch Repair
If you have been diagnosed with colon cancer that was surgically removed but has spread to lymph nodes and is known as stage III colon ...Phase
Interventional
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A Double Blind Placebo-Controlled Trial of Eflornithine and Sulindac to Prevent Recurrence of High Risk Adenomas and Second Primary Colorectal Cancers in Patients with Stage 0-III Colon or Rectal Cancer Phase III Preventing Adenomas of the Colon with Eflornithine and Sulindac (PACES)
If you have been diagnosed with colon or rectal cancer, you may qualify to participate in a study evaluating the combination of the drugs eflornithine ...
Phase
Interventional
