12 clinical trials found.
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A phase II open-label multicenter study of ONC201 in adults with recurrent histone H3 K27M mutant glioma
If you have been diagnosed with recurrent glioma (a type of brain tumor), you may be qualified to participate in this study evaluating the investigational ...Phase
Interventional
TRIAL ROLE: Principal Investigator
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A phase II open-label single arm trial of nivolumab ipilimumab and short-course radiotherapy in adults with newly diagnosed MGMT unmethylated glioblastoma
If you have been diagnosed with a form of brain cancer called glioblastoma and you have not received any therapy for your tumor other than ...Phase
Interventional
TRIAL ROLE: Principal Investigator
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Phase II Trial of BRAF/MEK Inhibitors in Papillary Craniopharyngiomas
The purpose of the study is to determine the safety and efficacy of the study drugs called vemurafenib and cobimetinib. We want to know if ...Phase
Interventional
TRIAL ROLE: Principal Investigator
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A Phase I/II Study of Nivolumab plus or minus Ipilimumab in Combination with Multi-fraction Stereotactic Radiosurgery for Recurrent High-grade Radiation-relapsed Meningioma
The purpose of the study is to examine the safety when combining nivolumab with or without ipilimumab (two different types of immunotherapy drugs) with radiosurgery ...Phase
Interventional
TRIAL ROLE: Principal Investigator
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A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C Mutation
The purpose of this study is to test the safety, tolerability, and effectiveness of MRTX849 (called “the study drug” from now on) for advanced cancers ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A PHASE II RANDOMIZED TRIAL OF PROTON VS. PHOTON THERAPY (IMRT) FOR COGNITIVE PRESERVATION IN PATIENTS WITH IDH MUTANT LOW TO INTERMEDIATE GRADE GLIOMAS
The purpose of this study is to compare any good and bad effects of using proton therapy to using photon therapy. Photon therapy is the ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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RANDOMIZED PHASE II TRIAL OF HYPOFRACTIONATED DOSE-ESCALATED PHOTON IMRT OR PROTON BEAM THERAPY VERSUS CONVENTIONAL PHOTON IRRADIATION WITH CONCOMITANT AND ADJUVANT TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA
The purpose of this study is to compare a different radiation therapy schedule and higher radiation dose [higher dose group] to the standard dose of ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A Multicenter Open-label Phase 2 Study of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) in Previously Treated Subjects with Selected Solid Tumors (LEAP-005)
The purpose of this study is to: o Test the safety of the study drugs, lenvatinib and pembrolizumab when given together o See how well ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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A single arm open-label multicenter phase II study of 177Lu-DOTATATE radionuclide in adults with progressive or high-risk meningioma
The purpose of this research study is to test whether Lutathera® (177Lu-DOTATATE) is effective (how well something works) at stopping the growth of meningiomas. This ...Phase
Interventional
TRIAL ROLE: Sub Investigator
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DART: DUAL ANTI-CTLA-4 AND ANTI-PD-1 BLOCKADE IN RARE TUMORS
If you have been diagnosed with a rare cancer or a rare cancer of unknown primary origin, you may qualify for this study. The main ...Phase
Interventional
TRIAL ROLE: Sub Investigator
