34 clinical trials found.
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A Master Protocol for the Multi-Cohort Phase 1/2 Study of DCC-3116 in Combination with Anticancer Therapies in Participants with Advanced Malignancies
This study is testing a medicine called DCC-3116 along with other cancer treatments for patients with advanced malignancies. The study team split the study into ...
Phase
TRIAL ROLE: Principal Investigator
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KontRASt-03: A Phase Ib/II multicenter open-label platform study of JDQ443 with select combinations in patients with advanced solid tumor harboring the KRAS G12C mutation
This study will focus on two types of cancer: non-small cell lung cancer and colorectal cancer. The purpose of the study is to find out ...
Phase
TRIAL ROLE: Principal Investigator
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AN OPEN-LABEL STUDY OF GV20-0251 IN PATIENTS WITH ADVANCED AND/OR REFRACTORY SOLID TUMOR MALIGNANCIES
This study has two parts, Part A and Part B, and will be testing the drug GV20-0251 to see how well it can help patients ...
Phase
TRIAL ROLE: Principal Investigator
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An open-label multi-center phase I dose finding study of oral TNO155 in adult patients with advanced solid tumors
This is a medical study for adults with advanced solid tumors. The study has two parts: the first part tests different doses of a drug ...
Phase
TRIAL ROLE: Principal Investigator
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A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients with Advanced Solid Tumors with KRAS G12C Mutation
The purpose of this study is to test the safety, tolerability, and effectiveness of MRTX849 (called “the study drug” from now on) for advanced cancers ...Phase
TRIAL ROLE: Sub Investigator
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A Phase 2 Randomized Study of Adjuvant Immunotherapy With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab Versus Pembrolizumab Alone After Complete Resection of High-Risk Melanoma (mRNA-4157-P201)
The purpose of this research study is to test whether the combination of the study drugs pembrolizumab and mRNA-4157 works better than just pembrolizumab to ...Phase
TRIAL ROLE: Sub Investigator
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A Phase 1/2 Multi-Center Open-Label Study to Evaluate the Safety Tolerability and Preliminary Antitumor Activity of TNG348 Single Agent and in Combination with a PARP Inhibitor in Patients with BRCA 1/2 Mutant or Other HRD+ Advanced or Metastatic S
This study is split into two parts: Phase 1 and Phase 2. The study team is testing a new medicine, TNG348, for patients with tumors ...
Phase
TRIAL ROLE: Sub Investigator
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A first-in-human Phase I non-randomized open-label multicentre dose escalation trial of BI 765049 and BI 765049 + ezabenlimab administered by repeated intravenous infusions in patients with malignant solid tumors expressing B7-H6
This study is testing different doses of a dtreatment called BI 765049, either alone or with another drug called ezabenlimab for patients with tumors expressing ...
Phase
TRIAL ROLE: Sub Investigator
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A Phase 3 Randomized Double-Blind Placebo- and Active-Comparator- Controlled Clinical study of Adjuvant V940 (mRNA-4157) Plus Pembrolizumab Versus Adjuvant Placebo Plus Pembrolizumab in Participants With High-Risk Stage II-IV Melanoma
This study wants to find out if a new treatment called V940, when used with pembrolizumab, has fewer side effects and is more effective than ...
Phase
TRIAL ROLE: Sub Investigator
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A Phase II Study of the Interleukin-6 Receptor Inhibitor Sarilumab in Combination with Ipilimumab Nivolumab and Relatlimab in Patients with Unresectable Stage III or Stage IV Melanoma
This study is looking at a treatment for advanced melanoma, a type of skin cancer. The study has two parts. First, patients will get a ...
Phase
TRIAL ROLE: Sub Investigator
