39 "Breast" clinical trials found.
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RANDOMIZED OPEN-LABEL STUDY OF THE BRIA-IMT REGIMEN AND CHECK POINT INHIBITOR VS PHYSICIAN'S CHOICE IN ADVANCED METASTATIC BREAST CANCER (BRIA-ABC)
This study is testing a new treatment called Bria-IMT (an experimental immunotherapy treatment) for patients with advanced breast cancer that has spread (metastatic) or come ...
Phase
Interventional
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RADIation after no Axillary Nodal Sampling (RADIANS)
This is a single arm, pilot, prospective study to evaluate the safety of partial breast irradiation in women who undergo breast conserving surgery without SLNB ...Phase
Interventional
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A PHASE Ib/II OPEN-LABEL MULTICENTER RANDOMIZED UMBRELLA STUDY EVALUATING THE EFFICACY AND SAFETY OF MULTIPLE TREATMENT COMBINATIONS IN PATIENTS WITH METASTATIC BREAST CANCER (MORPHEUS-panBC)
This is a Phase 1b/2 clinical study for people with metastatic (which is breast cancer that has spread to other parts of the body ...
Phase
Interventional
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A phase 1/2 first-in-human study to assess the safety tolerability pharmacokinetics pharmacodynamics and antitumor activity of AVZO-023 as a single agent and in combination with AVZO-021 and/or endocrine therapy in patients
This study is testing the new medicine, AVZO-023-1001 (CDK4 inhibitor), in patients with solid tumors that show changes in CDK/CCND1 genes and in patients ...
Phase
Interventional
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Elacestrant in Advanced Triple Positive Breast Cancer a Phase II Evaluation (ELATE)
This is a Phase 2 study testing how well a combination of medicines work in treating people with triple-positive breast cancer. The study is open-label ...
Phase
Interventional
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An Open-Label Randomized Multicenter Phase 3 Study Investigating the Efficacy and Safety of BGB-43395 Plus Letrozole versus CDK4/6 Inhibitors (Abemaciclib Palbociclib Ribociclib) Plus Letrozole in Patients with Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Systemic Anticancer Treatment for Advanced or Metastatic Disease
This is a Phase 3 study comparing BGB-43395 plus letrozole with the current standard treatment of an approved CDK4/6 inhibitor (abemaciclib, palbociclib, or ribociclib ...
Phase
Interventional
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I-SPY 2 TRIAL -Investigation of Serial Studies to Predict your Therapeutic Response with Imaging and Molecular Analysis 2
The I-SPY 2.2 protocol uses the same strategy as the I-SPY 2.0 protocol to optimize response, measuring the impact of each therapeutic regimen ...Phase
Interventional
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A Phase 3 randomized open-label multicenter controlled study to evaluate the efficacy and safety of zanidatamab in combination with physician s choice chemotherapy compared to trastuzumab in combination with physician s choice chemotherapy for the treatment of participants with metastatic HER2-positive breast cancer who have progressed on or are intolerant to previous trastuzumab deruxtecan treatment
This study tests a new treatment called zanidatamab against a standard treatment called trastuzumab. Both treatments will be given with chemotherapy chosen by the doctor ...
Phase
Interventional
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A Phase 1 First-in-Human Study of MEN2312 a KAT6 Inhibitor as Monotherapy and in Combination in Participants With Advanced Breast Cancer
This is the first study in people to test a new drug called MEN2312 (an experimental cancer drug) for the treatment of advanced breast cancer ...
Phase
Interventional
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Partial breast re-irradiation using ultra hypofractionation (PRESERVE) Phase 2 multi- institutional study
Partial breast re-irradiation using ultra hypofractionation (PRESERVE) Phase 2 multi- institutional studyPhase
Interventional
