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Randomized Phase 2 Study of Erdafitinib vs Investigator Choice of Chemo in Subjects Who Received BCG and Recurred With HR NMIBC (42756493BLC2003)
The purpose of the study is to determine the safety and efficacy of erdafitinib in subjects with Non-Muscle-Invasive Bladder Cancer (NMIBC) and fibroblast growth factor ...Phase
Interventional
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A Phase 1/2 Study of EG-70 as an Intravesical Administration to Patients with BCG-Unresponsive NMIBC
The purpose of the study is to evaluate the safety and efficacy of intravesical administration of EG-70 and its effect on bladder tumors in patients ...Phase
Interventional
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A Phase 3 Randomized Double-blind Matching Placebo-controlled Clinical Trial to Study the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) versus CRT Alone in Participants with MIBC (KEYNOTE-992)
The purpose of the study is to determine the safety and efficacy of Pembrolizumab (MK-3475) and Chemoradiotherapy (CRT) for people who have muscle-invasive bladder cancer ...Phase
Interventional
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A Phase 3 Randomized Double-blind Study to Evaluate Perioperative Pembrolizumab (MK-3475) + Neoadjuvant Chemotherapy versus Perioperative Placebo + Neoadjuvant Chemotherapy in Cisplatin-eligible Participants with Muscle-invasive Bladder Cancer (KEYNOTE-866)
This is a research study involving the drug pembrolizumab. The purpose of this study is to: o See if the study drug, pembrolizumab, in combination ...Phase
Interventional
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A Multicenter Clinical Trial of Intravesical Bacillus Calmetter-Guerin (BCG) in combination with ALT-803 in Patients with BCG Unresponsive High Grade non-Muscle Invasive Bladder Cancer
The purpose of the study is to assess effectiveness and safety of the intravesical BCG (Bacillus Calmetter-Guerin) in combination with ALT-803 in patients with BCG ...Phase
Interventional
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A Phase 3 Randomized Comparator-controlled Study of the Efficacy and Safety of Pembro in Comb. with BCG in Participants with HR Non-muscle Invasive Bladder Cancer (HR NMIBC) that is Persistent or Recurrent Following BCG Induction
The purpose of the study is to test the safety of the study drugs, pembrolizumab in combination with Bacillus Calmette-Guerin (BCG) and we want to ...Phase
Interventional
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A study of intravesical enfortumab vedotin for treatment of patients with non-muscle invasive bladder cancer (NMIBC)
The purpose of the study is to determine and evaluate the safety, tolerability, and systemic exposure of intravesical enfortumab vedotin. We want to identify the ...Phase
Interventional
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Site for 10144 - A Phase II Study of Olaparib (AZD2281) in Patients with Metastatic/Advanced Urothelial Carcinoma with DNA-Repair Defects
The purpose of the study is to determine if olaparib works in treating patients with urothelial cancer with deoxyribonucleic acid (DNA)-repair defects that has ...Phase
Interventional
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A Phase II Open Label Study of IMMU-132 in Metastatic Urothelial Cancer After Failure of Platinum-Based Regimen or Anti-PD-1 / PD-L1 Based Immunotherapy
If you have been diagnosed with urothelial cancer that has progressed or returned, you may be qualified for this Phase 2 study. The main goal ...Phase
Interventional
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A Phase 3 Randomized Open-Label Three Arm Study of PF-06801591 in Combination with BCG (Induction With or Without Maintenance) Versus BCG (Induction and Maintenance) in Participants with HR BCG-Na ve NMIBC (B8011006)
The purpose of the study is to determine the safety and efficacy of PF-06801591 (an anti-PD-1 antibody) combined with Bacillus Calmette- Guerin (BCG) in patients ...Phase
Interventional
