Displaying 219 (all) recruiting clinical trials.
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BAF-FRontier-1 A First-in-Human Phase 1a/1b Trial to Assess Safety Tolerability and Preliminary Efficacy of LY4152199 a B-cell Activation Factor Receptor (BAFF-R) T-Cell Engager Bispecific Antibody in Adult Participants with Previously Treated Bcell Malignancies
The purpose of this study is to measure the safety and efficacy of LY4152199 in participants with previously treated B-cell lymphoma and leukemia. This study ...Phase
Interventional
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A Phase 1 Multicenter Open-Label Dose-Escalation Study to Assess Safety Tolerability and Efficacy of EXS74539 as Monotherapy in Participants with Select Solid Tumors
This is a Phase 1 study testing a new oral drug called EXS74539 in patients with small cell lung cancer (SCLC) and other selected solid ...
Phase
Interventional
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A Phase 1b Open-Label Multicenter Study to Evaluate the Safety and Preliminary Efficacy of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjects
This is a Phase 1b study testing a combination of two medicines, cemsidomide and elranatamab, in patients with relapsed or hard-to-treat multiple myeloma (a type ...
Phase
Interventional
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A Phase 1a/1b Study of LY4052031 an Antibody-Drug Conjugate Targeting Nectin-4 in Participants with Advanced or Metastatic Urothelial Carcinoma or Other Solid Tumors
This is a Phase 1a/1b study testing a new drug called LY4052031 (an experimental cancer drug) in patients with advanced cancers, including bladder (urothelial ...
Phase
Interventional
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A Phase 1 First-in-human Dose Escalation Study of JNJ-95804306 for Relapsed or Refractory Hematological Malignancies
This is an early-stage (Phase 1) study testing a new drug called JNJ-95804306 (an experimental cancer drug) in people with certain blood cancers, including acute ...
Phase
Interventional
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Phase III trial of radiotherapy followed by adjuvant temozolomide in combination with the IDH inhibitor vorasidenib vs. placebo in IDH-mutated newly-diagnosed grade 3 astrocytoma
This is a Phase III study for people with newly diagnosed grade 3 astrocytoma that has a mutation in the IDH (mIDH) gene. All participants ...
Phase
Interventional
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A PHASE II SINGLE-ARM SINGLE-CENTER STUDY EVALUATING TOXICITY OUTCOMES AND DOSIMETRY USING AN MR-GUIDED LINEAR ACCELERATOR FOR THE TREATMENT OF EARLY STAGE KIDNEY CANCER
This Phase II single arm study will prospectively enroll 30 patients. Patients have a simulation visit, where treatment planning includes an MRI scan to check ...Phase
Interventional
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A Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for HOPE Patients with Hematologic Malignancies or Disorders
This in an expanded access program (EAP) to provide donor bone marrow to patients meeting eligibility criteria as well as safety in its use as ...Phase N/A Interventional
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A PHASE Ib/II OPEN-LABEL MULTICENTER RANDOMIZED UMBRELLA STUDY EVALUATING THE EFFICACY AND SAFETY OF MULTIPLE TREATMENT COMBINATIONS IN PATIENTS WITH METASTATIC BREAST CANCER (MORPHEUS-panBC)
This is a Phase 1b/2 clinical study for people with metastatic (which is breast cancer that has spread to other parts of the body ...
Phase
Interventional
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HYPO2-BOOST GBM trial: Hypoxia-targeted radiotherapy boost for GBM
This is a Phase 1/2 study that will be testing whether a special MRI scan, called dynamic contrast-enhanced MRI (DSC-MRI), can help doctors find ...
Phase
Interventional
