Displaying 178 (all) recruiting clinical trials.
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PH II study of adjuvant tx with cisplatin-based chemotherapy plus concomitant atezolizumab in patients with stage I (tumors > 4cm) IIA IIB and select IIIA [T3N1 T4N0-1] resected NSCLC and the clearance of (ctDNA)
The purpose of the study is to determine and estimate the percentage of patients with undetectable circulating tumor DNA (ctDNA) after 4 cycles of adjuvant ...Phase
Interventional
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A Phase 2 Multicenter Open-label Study of Sotorasib (AMG 510) in Subjects with Stage IV NSCLC Whose Tumors Harbor a KRASG12C Mutation in Need of First-line Treatment (CodeBreaK 201)
The purpose of the study is to determine the anti-tumor effect (safety and tolerability) of sotorasib monotherapy in subjects with metastatic non-small cell lung cancer ...Phase
Interventional
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A randomized phase II trial of adjuvant trastuzumab emtansine (T-DM1) followed by subcutaneous trastuzumab versus paclitaxel in combination with subcutaneous trastuzumab for Stage I HER2-positive breast cancer (ATEMPT 2.0)
In stage 1 (early) HER2+ breast cancer, lesser chemotherapy is needed to achieve excellent long-term survival. The current standard therapy is TH (paclitaxel plus trastuzumab ...Phase
Interventional
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A Phase I Open-Label Multicenter Study of FT596 as a Monotherapy and in Combination with Rituximab or Obinutuzumab in Subjects with Relapsed/Refractory B-cell Lymphoma and Chronic Lymphocytic Leukemia
The purpose of the study is to determine the recommended phase 2 dose for FT596 as monotherapy and in combination with rituximab or obinutuzumab for ...Phase
Interventional
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A Phase II Study of Biomarker Driven Early Discontinuation of Anti-PD-1 Therapy in Patients with Advanced Melanoma (PET-Stop) [EA6192]
The purpose of the study is to evaluate and determine how well biomarkers on PET/CT imaging drive early discontinuation of anti-PD-1 therapy in patients ...Phase
Interventional
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A Phase 1/2 Study of M3814 (peposertib) in Combination with Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma ( s21-00991)
The purpose of the study is to determine the side effects and best dose of M3814. We want to see how well the drug M3814 ...Phase
Interventional
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A Phase 2 Randomized Open-Label Study Evaluating the Safety and Efficacy of Magrolimab in Combination with Nab-Paclitaxel or Paclitaxel versus Nab-Paclitaxel or Paclitaxel in Previously Untreated Patients with Metastatic Triple-Negative Breast Cancer
Magrolimab is a novel immune checkpoint inhibitor (targeting macrophages in the tumor to support killing of tumor). The purpose of the study is to determine ...Phase
Interventional
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Single-arm open label phase II study of MBG453 (sabatolimab) added to FDA approved Hypomethylating agents of investigator s choice (IV/SC/Oral) for patients with intermediate high or very high risk myelodysplastic syndrome (MDS) as per IPSS-R criteria (US multi-center) (STIMULUS MDS-US)
The purpose of the study is to describe and evaluate safety and efficacy of MBG453 (sabatolimab) in combination with FDA approved Hypomethylating agents (HMA). We ...Phase
Interventional
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The BAMM2 (BRAF Autophagy MEK inhibition in Melanoma) Study: A Randomized Double Blind Phase II Study of Dabrafenib and Trametinib with or without Hydroxychloroquine in Advanced BRAFV600E/K Melanoma with elevated LDH
Hydroxychloroquine inhibits a process called autophagy which helps tumors survive. The purpose of the study is to see how well different treatments work when hydroxychloroquine ...
Phase
Interventional
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A Phase 2 Study of BA3011 Alone and in Combination with Nivolumab in Adult Patients with Metastatic Non-Small Cell Lung Cancer (NSCLC) Who Had Prior Disease Progression on a PD-1/L-1 Inhibitor
The purpose of the study is designed to evaluate the efficacy and safety of BA3011 alone and in combination with nivolumab in patients with AXL-expressing ...Phase
Interventional
