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The AIM-HN and SEQ-HN Study: A 2 Cohort Non-comparative Pivotal Study Evaluating the Efficacy of Tipifarnib in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC) with HRAS Mutations (AIM-HN) and the Impact of HRAS Mutations on Response to First Line Systemic Therapies for HNSCC (SEQ-HN)
The purpose of this research study is to see how effective the study drug is to treat your tumor. Other reasons for conducting the study ...Phase N/A
Interventional
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Precision Promise Platform Trial for Metastatic Pancreatic Cancer Precision PromiseSM
The purpose of this study is to hope that Precision PromiseSM will change the landscape of clinical development in pancreatic cancer and open the door ...Phase N/A Interventional
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SpotCheck: Comparison of Enhanced Telemedicine Versus In-Person Evalution for the Diagnosis of Skin Cancer.
The aim of this pilot is to test a novel, telemedicine-based skin lesion diagnostic platform (SpotCheck) that has the potential to improve access to needed ...
Phase N/A Interventional
Accepts Healthy Volunteer
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Expanded Access to ONC201 for Patients with H3 K27M-mutant and/or Midline Gliomas
The purpose of this research study is to provide ONC201 to patients with specific forms of brain cancer who cannot access ONC201 by participating in ...Phase N/A Interventional
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Surveillance After Extremity Tumor Surgery International Randomized Controlled Trial
The purpose of this research study is to determine whether the frequency of follow-up after surgery (visits every 3 months vs every 6 months) or ...Phase N/A Interventional
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Photobiomodulation Therapy Using the MuReva Phototherapy System to Demonstrate Safety and Reduce the Incidence of Oral Mucositis in Adult Patients with Head and Neck Cancer Receiving Concurrent Radiation and Chemotherapy
The overall purpose of this clinical study is to evaluate safety and efficacy of the MuReva Phototherapy System with a light delivery mouthpiece to reduce ...Phase N/A Interventional
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Prospective Randomized Placebo-Controlled Trial of SurVaxM Plus Adjuvant Temozolomide for Newly Diagnosed Glioblastoma (SURVIVE)
You can participate in this study if you are newly diagnosed with brain cancer (glioblastoma). The purpose of this study is to evaluate a peptide ...Phase N/A Interventional
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NRG-BR007: A PHASE III CLINICAL TRIAL EVALUATING DE-ESCALATION OF BREAST RADIATION FOR CONSERVATIVE TREATMENT OF STAGE I HORMONE SENSITIVE HER2-NEGATIVE ONCOTYPE RECURRENCE SCORE = 18 BREAST CANCER
The purpose of the study is to determine and examine whether breast conservation surgery and endocrine therapy results in a non-inferior rate of ipsilateral-breast tumor ...Phase N/A
Non-Interventional
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Compassionate Use of Pirtobrutinib for a Patient with Waldenstrom s macroglobulinemia.
You can participate in this study if you are diagnosed with Waldenstrom’s macroglobulinemia. In this study we will evaluate the study drug (Pirtobrutinib) for ...
Phase N/A Interventional
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Characterization of objective skin color changes during and after breast and chest wall radiotherapy and correlation with radiation-induced skin toxicity in breast cancer patients including patients with skin of color
The purpose of this study is to objectively evaluate skin color changes during and after standard of care breast or chest wall radiotherapy using spectrophotometry ...
Phase N/A Non-Interventional
