Displaying 42 (all) recruiting clinical trials.
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An Open-label Single-Arm Phase 2 Study to Evaluate Enfortumab Vedotin plus Pembrolizumab for Bladder Preservation in Participants with Muscle-invasive Bladder Cancer
This is a global, open-label, phase 2 study in adult participants with histologically confirmed MIBC (stage cT2–T4aN0M0 or T1-T4aN1M0) who are eligible for RC ...Phase
Interventional
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A Phase 2 multicenter clinical study to evaluate the efficacy and safety of safusidenib erbumine in patients with isocitrate dehydrogenase 1 (IDH1)-mutant glioma
This is a Phase 2 study testing whether the new drug, safusidenib, is safe and effective in patients with glioma, a type of brain tumor ...
Phase
Interventional
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A Phase 2 Randomized Blinded Placebo-Controlled Trial Investigating the Efficacy and Safety of Visugromab versus Placebo in Combination with Pembrolizumab Pemetrexed and Carboplatin in First-Line Treatment of Participants with Metastatic Non-Squamous Non-Small Cell Lung Cancer (GDFATHER-NSCLC-01)
This is a Phase 2 study testing a new medicine called Visugromab (also called CTL-002) to see how well it works with standard cancer treatments ...
Phase
Interventional
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A Phase 2 Multicenter Open-Label Study Evaluating the Efficacy and Safety of TYRA-300 in Participants with FGFR3 Altered Low Grade Intermediate Risk Non-Muscle Invasive Bladder Cancer
This study will investigate the safety, tolerability of TYRA-300 and assess different doses of TYRA-300 in participants harboring FGFR3 mutations and/or fusions with intermediate ...Phase
Interventional
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Safely Optimizing Body Weight with TCMCB07 in Patients with Newly Diagnosed Metastatic Colorectal Cancer Undergoing Chemotherapy
This is a study testing different doses of a drug called B07 (an experimental drug) to see how it affects body weight, BMI (body mass ...
Phase
Interventional
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A Phase 2 study to investigate efficacy safety tolerability and pharmacokinetics of JZP3507 (ONC206) in adults with recurrent Grade 2 or 3 Meningioma
This is a Phase 2 study testing a new drug called JZP3507 (an investigational anti-cancer drug) in patients with Grade 2 or Grade 3 meningioma ...
Phase
Interventional
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Randomized Phase 2 Trial of Ruxolitinib in Combination with Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma
This is a Phase 2 study testing a new treatment approach for newly diagnosed glioblastoma. It compares ruxolitinib plus radiation and temozolomide to the standard ...
Phase
Interventional
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A Phase 2 Open-label Study of VS-7375 an Oral KRAS G12D (ON/OFF) Inhibitor as Monotherapy and with Cetuximab in Patients with Metastatic KRAS G12D-Mutated Pancreatic Cancer (TARGET-D 201)
This is a Phase 2, open-label study for adults with metastatic pancreatic cancer that has a KRAS G12D gene mutation. The study is testing an ...
Phase
Interventional
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A Multi-center Phase 2 Study of Hippocampal Avoidance in Craniospinal Irradiation for Leptomeningeal Metastases from Solid Tumors
This is a Phase 2 clinical study done at multiple hospitals that is testing a special type of radiation treatment called craniospinal irradiation (CSI) with ...
Phase
Interventional
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A PHASE II SINGLE-ARM SINGLE-CENTER STUDY EVALUATING TOXICITY OUTCOMES AND DOSIMETRY USING AN MR-GUIDED LINEAR ACCELERATOR FOR THE TREATMENT OF EARLY STAGE KIDNEY CANCER
This Phase II single arm study will prospectively enroll 30 patients. Patients have a simulation visit, where treatment planning includes an MRI scan to check ...Phase
Interventional
