Displaying 147 (all) recruiting clinical trials.
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A Phase II Study of Biomarker Driven Early Discontinuation of Anti-PD-1 Therapy in Patients with Advanced Melanoma (PET-Stop) [EA6192]
The purpose of the study is to evaluate and determine how well biomarkers on PET/CT imaging drive early discontinuation of anti-PD-1 therapy in patients ...Phase
Interventional
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A Phase 1/2 Study of M3814 (peposertib) in Combination with Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma ( s21-00991)
The purpose of the study is to determine the side effects and best dose of M3814. We want to see how well the drug M3814 ...Phase
Interventional
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A Phase 2 Randomized Open-Label Study Evaluating the Safety and Efficacy of Magrolimab in Combination with Nab-Paclitaxel or Paclitaxel versus Nab-Paclitaxel or Paclitaxel in Previously Untreated Patients with Metastatic Triple-Negative Breast Cancer
Magrolimab is a novel immune checkpoint inhibitor (targeting macrophages in the tumor to support killing of tumor). The purpose of the study is to determine ...Phase
Interventional
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The BAMM2 (BRAF Autophagy MEK inhibition in Melanoma) Study: A Randomized Double Blind Phase II Study of Dabrafenib and Trametinib with or without Hydroxychloroquine in Advanced BRAFV600E/K Melanoma with elevated LDH
Hydroxychloroquine inhibits a process called autophagy which helps tumors survive. The purpose of the study is to see how well different treatments work when hydroxychloroquine ...
Phase
Interventional
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A Phase 2 Study of BA3011 Alone and in Combination with Nivolumab in Adult Patients with Metastatic Non-Small Cell Lung Cancer (NSCLC) Who Had Prior Disease Progression on a PD-1/L-1 Inhibitor
The purpose of the study is designed to evaluate the efficacy and safety of BA3011 alone and in combination with nivolumab in patients with AXL-expressing ...Phase
Interventional
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Phase II Trial of Radium-223 Dichloride in Combination with Paclitaxel in Patients with Bone Metastatic Breast Cancer
The purpose of the study is to determine the safety and efficacy of the combination of Radium-223 dichloride and paclitaxel. We want to know if ...Phase
Interventional
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An Open Label First in Human (FIH) Phase 1 Trial of LVGN6051 as Single Agent and in Combination with Keytruda (pembrolizumab) in Advanced or Metastatic Malignancy
The purpose of the study is to look at how your body tolerates LVGN6051, how safe LVGN6051 may be, and how LVGN6051 is taken up ...Phase
Interventional
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A Phase 1/2 Dose Escalation And Dose Expansion Study Of BA3021 Alone And In Combination With Nivolumab In Patients With Advanced Solid Tumors
The purpose of the study is to determine and evaluate the safety, tolerability, immunogenicity, and antitumor activity of BA3021 alone and in combination with nivolumab ...Phase
Interventional
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A Phase 1/2 Study of EG-70 as an Intravesical Administration to Patients with BCG-Unresponsive NMIBC
The purpose of the study is to evaluate the safety and efficacy of intravesical administration of EG-70 and its effect on bladder tumors in patients ...Phase
Interventional
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Randomized Phase 2 Study of Erdafitinib vs Investigator Choice of Chemo in Subjects Who Received BCG and Recurred With HR NMIBC (42756493BLC2003)
The purpose of the study is to determine the safety and efficacy of erdafitinib in subjects with Non-Muscle-Invasive Bladder Cancer (NMIBC) and fibroblast growth factor ...Phase
Interventional
