Displaying 181 (all) recruiting clinical trials.
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Pre-Approval Access to Amivantamab in Patients with Metastatic Non-Small Cell Lung Cancer with EGFR Exon 20 Insertion Mutations who have Failed Platinum-Based Chemotherapy
The purpose of this Expanded Access Program (EAP) is for patients with metastatic non-small cell lung cancer (NSCLC) who have EGFR exon 20 insertion mutations ...Phase N/A
Interventional
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Site for Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered with Concurrent Cisplatin Versus Docetaxel Versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of the Head and Neck
The purpose of the study is to determine whether docetaxel alone is as active as docetaxel and cetuximab combination and whether either taxane-based regimen is ...Phase
Interventional
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A Phase 3 Randomized Comparator-controlled Study of the Efficacy and Safety of Pembro in Comb. with BCG in Participants with HR Non-muscle Invasive Bladder Cancer (HR NMIBC) that is Persistent or Recurrent Following BCG Induction
The purpose of the study is to test the safety of the study drugs, pembrolizumab in combination with Bacillus Calmette-Guerin (BCG) and we want to ...Phase
Interventional
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An Open-label Single-arm Single-dose Prospective Multicenter Phase 2b Study to Establish Image Interpretation Criteria for 18F-Fluciclovine Positron Emission Tomography (PET) in Detecting Recurrent Brain Metastases after Radiation Therapy (PURSUE)
The purpose of the study is to establish visual image interpretation criteria and safety for 18F-fluciclovine Positron Emission Tomography (PET) in detecting recurrent brain metastases ...Phase
Interventional
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A PHASE II SINGLE-ARM STUDY OF TOTAL BODY IRRADIATION WITH LINAC BASED VOLUMETRIC MODULATED ARC THERAPY (VMAT) AND IMAGE GUIDED RADIATION THERAPY (IGRT)
The purpose of the study is to determine the safety and efficacy of delivering total body irradiation (TBI) with linac based VMAT technique for patients ...Phase
Interventional
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A Phase 2 Umbrella Study with Rolling Arms of Investigational Agents with either Pembrolizumab in Combination with Chemotherapy or with Pembrolizumab Alone in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
The purpose of the study is to determine how well different drugs work in a single type of cancer for patients with advanced NSCLC. This ...Phase
Interventional
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Phase 2 Multicenter Randomized Study of DS-1062a in Advanced or Metastatic NSCLC w/ Actionable Genomic Alterations and Previously Treated with Kinase Inhibitor Therapy and Platinum-based Chemotherapy w/ or w/o Prior Immunotherapy
The purpose of the study is to evaluate the efficacy and safety of DS-1062a in subjects with advanced or metastatic Non-Small Cell Lung Cancer (NSCLC ...Phase
Interventional
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A PHASE 1 OPEN-LABEL DOSE FINDING STUDY OF CC-95251 A MONOCLONAL ANTIBODY DIRECTED AGAINST SIRPa ALONE AND IN COMBINATION WITH CETUXIMAB OR RITUXIMAB IN SUBJECTS WITH ADVANCED SOLID AND HEMATOLOGIC CANCERS
The purpose of the study is to look at how your body tolerates CC-95251 and safety of the CC-95251 when administered intravenously (IV) as single ...Phase
Interventional
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An Open-label Multicenter Multicohort Phase 2 Study to Evaluate Enfortumab Vedotin in Subjects with Previously Treated Locally Advanced or Metastatic Malignant Solid Tumors
The purpose of the study is to assess the antitumor activity and safety of enfortumab vedotin as a single agent in adult subjects who have ...Phase
Interventional
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Randomized Phase II Trial of Topotecan plus M6620 (VX-970) vs. Topotecan alone in Patients with Relapsed Small-Cell Lung Cancer
The purpose of the study is to determine the efficacy of topotecan in combination with M6620 or topotecan alone for Relapsed Small-Cell Lung Cancer (SCLC ...Phase
Interventional
