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A Study of a Selective ERBB2 Inhibitor CGT4255 in Patients With Advanced Solid Tumors With ERBB2 Genetic Alterations or HER2 Overexpression
This is a study testing a new medicine called CGT4255 for patients with advanced cancers (like lung cancer or breast cancer) that have certain mutations ...
Phase
Interventional
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A Phase 1/2 Open-Label Multicenter First-in-Human Study of the Safety Tolerability Pharmacokinetics and Antitumor Activity of BH-30643 in Adult Subjects with Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations (SOLARA)
This is a Phase 1/2 study testing a medicine called BH-30643, a new drug that targets and blocks specific mutations (changes) in two proteins ...
Phase
Interventional
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AN OPEN-LABEL PHASE 1 SAFETY AND DOSE FINDING STUDY OF ORALLY ADMINISTERED GLIX1 IN ADULTS WITH RECURRENT OR PROGRESSIVE HIGH-GRADE GLIOMA
This is an open label (meaning both doctors and participants know what treatment is given), first study in humans, done at several medical centers, for ...
Phase
Interventional
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INSIGHT MRL: Phase I Trial of INtenSIfication of Glioblastoma Hypofractionated Treatment on the MR-Linac
This is a phase 1 study to examine the safety and tolerability of biology-guided dose intensified hypofractionated radiation therapy (RT) using MR-Linac for patients with ...Phase
Interventional
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A PHASE 1 OPEN-LABEL MULTICENTER STUDY OF JANX007 IN SUBJECTS WITH METASTATIC CASTRATION-RESISTANT PROSTATE CANCER
This study is a first-in-human (FIH), Phase 1, open-label, multicenter study to assess the safety, tolerability, PK, PD, and preliminary efficacy of JANX007 administered as ...Phase
Interventional
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A Phase 1 First-in-Human Study to Investigate the Safety Pharmacokinetics and Preliminary Efficacy of ML261 an Autologous Anti-DLL3 CAR + CARD11-PIK3R3 Fusion T cell therapy in Participants with Relapsed/Refractory Small Cell Lung Cancer or Select Neuroendocrine Carcinomas
This is a Phase 1, first-in-human study that is testing a new treatment called ML261 for people with certain types of cancer, specifically small cell ...
Phase
Interventional
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A Phase 1b Study Evaluating the Safety Tolerability pharmacokinetics and Efficacy of Tarlatamab in Combination with ZL-1310 with or without Anti-PD-L1 in Participants with Small Cell Lung Cancer
This is a Phase 1b study testing tarlatamab together with ZL-1310 (an investigational drug), with or without an immune therapy called anti-PD-L1 (durvalumab), in people ...
Phase
Interventional
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Phase 1/1b Multicenter Open-Label Study of RMC-5127 in Patients with Advanced KRAS G12V-Mutant Solid Tumors
This is a Phase 1/1b study testing RMC-5127 (investigational cancer drug) in adults with advanced solid tumors that have a KRAS G12V mutation, a ...
Phase
Interventional
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An Open-label Phase 1a/b Multicenter Study of ZL-6201 to Evaluate Safety Tolerability Pharmacokinetics and Preliminary Efficacy in Participants with Sarcoma and Selected Solid Tumors
This is a Phase 1 study testing a new medicine called ZL-6201 (an experimental antibody-drug conjugate - ADC) in patients with advanced bone sarcomas, soft tissue ...
Phase
Interventional
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BAF-FRontier-1 A First-in-Human Phase 1a/1b Trial to Assess Safety Tolerability and Preliminary Efficacy of LY4152199 a B-cell Activation Factor Receptor (BAFF-R) T-Cell Engager Bispecific Antibody in Adult Participants with Previously Treated Bcell Malignancies
The purpose of this study is to measure the safety and efficacy of LY4152199 in participants with previously treated B-cell lymphoma and leukemia. This study ...Phase
Interventional
