Displaying 40 (all) recruiting clinical trials.
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A Phase I Clinical Study to Evaluate the Safety Tolerability Pharmacokinetics and Clinical Activity of GSK5733584 for Injection in Subjects with Advanced Solid Tumors
This is a Phase 1 study testing the study medicine GSK5733584 (B7-H4 targeted antibody-drug conjugate (ADC )) in patients with advanced solid tumors. The study drug ...
Phase
Interventional
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A Phase 1 Open-Label Multicenter Study of INCA33890 in Participants With Advanced or Metastatic Solid Tumors
To evaluate the safety, tolerability, and DLTs and determine the MTD and/or RDE(s) of INCA33890 in participants with select advanced or metastatic solid ...Phase
Interventional
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A PHASE 1A/B OPEN-LABEL MASTER STUDY OF PF-07799544 AS A SINGLE-AGENT AND IN COMBINATION WITH OTHER TARGETED AGENTS IN PARTICIPANTS WITH BRAF-MUTANT MELANOMA AND OTHER SOLID TUMORS
This is a first-in-human, open-label, Phase 1a/b master protocol to evaluate safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary clinical activity of PF-07799544 (also ...Phase
Interventional
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A Phase 1 Study of ICP-248 in Combination with Azacitidine for the Treatment in Patients with Myeloid Malignancies
This is a phase 1, open-label, multicenter study with two parts that will assess the safety profile, PK profile, and preliminary efficacy of ICP-248 in ...Phase
Interventional
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A Phase I Trial Combining Triapine with Radiation Therapy for Recurrent Glioblastoma or Astrocytoma
This is a Phase 1 study testing the safety and effectiveness of a medicine called triapine, along with radiation therapy for patients who have recurring ...
Phase
Interventional
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A Phase 1 First-in-Human Study of MEN2312 a KAT6 Inhibitor as Monotherapy and in Combination in Participants With Advanced Breast Cancer
This is the first study in people to test a new drug called MEN2312 (an experimental cancer drug) for the treatment of advanced breast cancer ...
Phase
Interventional
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A Study of a Selective ERBB2 Inhibitor CGT4255 in Patients With Advanced Solid Tumors With ERBB2 Genetic Alterations or HER2 Overexpression
This is a study testing a new medicine called CGT4255 for patients with advanced cancers (like lung cancer or breast cancer) that have certain mutations ...
Phase
Interventional
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A Phase 1/2 Open-Label Multicenter First-in-Human Study of the Safety Tolerability Pharmacokinetics and Antitumor Activity of BH-30643 in Adult Subjects with Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations (SOLARA)
This is a Phase 1/2 study testing a medicine called BH-30643, a new drug that targets and blocks specific mutations (changes) in two proteins ...
Phase
Interventional
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AN OPEN-LABEL PHASE 1 SAFETY AND DOSE FINDING STUDY OF ORALLY ADMINISTERED GLIX1 IN ADULTS WITH RECURRENT OR PROGRESSIVE HIGH-GRADE GLIOMA
This is an open label (meaning both doctors and participants know what treatment is given), first study in humans, done at several medical centers, for ...
Phase
Interventional
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INSIGHT MRL: Phase I Trial of INtenSIfication of Glioblastoma Hypofractionated Treatment on the MR-Linac
This is a phase 1 study to examine the safety and tolerability of biology-guided dose intensified hypofractionated radiation therapy (RT) using MR-Linac for patients with ...Phase
Interventional
