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A Phase 2 Study of the PARP Inhibitor Olaparib (AZD2281) in IDH1 and IDH2 mutant Advanced Solid Tumors
The purpose of the study is to determine the overall response rates as well as safety and tolerability of olaparib in subjects with recurrent/progressive ...Phase
Interventional
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Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2)
The purpose of the study is to evaluate the biological activity of systemic therapies in people with Neurofibromatosis type 2 (NF2) related tumors. Tumor types ...Phase
Interventional
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Phase II pilot study of FOLFOXIRI plus panitumumab in metastatic RAS wild-type left-sided colorectal cancer
The purpose of this study is to evaluate the effectiveness (percent of patients with measurable response) of FOLFOXIRI and panitumumab for treatment of metastatic left ...Phase
Interventional
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A Phase II Basket Trial of Glutaminase Inhibitor (BeGIN) CB-839 HCl in Patients with NF1 Aberrations NF1 Mutant Malignant Peripheral Nerve Sheath Tumors (MPNST) KEAP1/NRF2 and LKB1 Aberrant Tumors
The purpose of the study is to determine the safety and tolerability of Glutaminase Inhibitor (BeGIN) CB-839 HCl in patients with NF1 mutant malignant peripheral ...Phase
Interventional
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A Phase 2 Study of Savolitinib in Subjects with MET Amplified Metastatic Colorectal Cancer
The purpose of the study is to determine how well savolitinib works in treating patients with MET amplified colorectal cancer that has spread to other ...Phase
Interventional
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A randomized open-label multi-arm two-part phase II study to assess efficacy and safety of multiple LXH254 combinations in patients with previously treated unresectable or metastatic BRAFV600 or NRAS mutant melanoma
The purpose of the study is to evaluate whether LXH254 may help overcome intrinsic and acquired resistance to BRAF targeted therapy and whether it can ...Phase
Interventional
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A PHASE IB-II STUDY OF HIGH-DOSE POST-TRANSPLANT CYCLOPHOSPHAMIDE BORTEZOMIB ABATACEPT AND SHORT-DURATION TACROLIMUS FOR THE PREVENTION OF GRAFT-VERSUS-HOST DISEASE (GVHD) FOLLOWING HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT)
The purpose of the study is to determine the safety and efficacy of cyclophosphamide, abatacept, and short-duration tacrolimus for GvHD prophylaxis following haploidentical hematopoietic stem ...Phase
Interventional
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An Open-label Single-arm Single-dose Prospective Multicenter Phase 2b Study to Establish Image Interpretation Criteria for 18F-Fluciclovine Positron Emission Tomography (PET) in Detecting Recurrent Brain Metastases after Radiation Therapy (PURSUE)
The purpose of the study is to establish visual image interpretation criteria and safety for 18F-fluciclovine Positron Emission Tomography (PET) in detecting recurrent brain metastases ...Phase
Observational
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A PHASE II SINGLE-ARM STUDY OF TOTAL BODY IRRADIATION WITH LINAC BASED VOLUMETRIC MODULATED ARC THERAPY (VMAT) AND IMAGE GUIDED RADIATION THERAPY (IGRT)
The purpose of the study is to determine the safety and efficacy of delivering total body irradiation (TBI) with linac based VMAT technique for patients ...Phase
Interventional
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A Phase 2 Umbrella Study with Rolling Arms of Investigational Agents with either Pembrolizumab in Combination with Chemotherapy or with Pembrolizumab Alone in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC)
The purpose of the study is to determine how well different drugs work in a single type of cancer for patients with advanced NSCLC. This ...Phase
Interventional
