Displaying 63 (all) recruiting clinical trials.
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MULTICENTER PHASE II NEOADJUVANT AND ADJUVANT STUDY OF ALECTINIB ENTRECTINIB OR VEMURAFENIB PLUS COBIMETINIB IN PATIENTS WITH STAGES I-III NON-SMALL CELL LUNG CANCER WITH ALK ROS1 NTRK OR BRAF V600E MOLECULAR ALTERATIONS
The purpose of the trial is to determine the efficacy and safety of drugs in patients with untreated non-small cell lung cancer (NSCLC) tumors. In ...Phase
Interventional
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Site for EA1181 (CompassHER2-pCR): Preoperative THP and postoperative HP in patients who achieve a pathologic complete response
The purpose of the study is to determine the safety and tolerability of pre-operative therapy with 12 weeks of taxane, trastuzumab (or FDA approved biosimilar ...Phase
Interventional
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A Phase 2 Study of the PARP Inhibitor Olaparib (AZD2281) in IDH1 and IDH2 mutant Advanced Solid Tumors
The purpose of the study is to determine the overall response rates as well as safety and tolerability of olaparib in subjects with recurrent/progressive ...Phase
Interventional
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Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2)
The purpose of the study is to evaluate the biological activity of systemic therapies in people with Neurofibromatosis type 2 (NF2) related tumors. Tumor types ...Phase
Interventional
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A Phase 2 Open-Label Single-Arm Multicenter Study to Evaluate the Efficacy and Safety of Pemigatinib in Participants With Previously Treated Locally Advanced/Metastatic or Surgically Unresectable Solid Tumor
To evaluate the efficacy of pemigatinib in participants with locally advanced/metastatic or surgically unresectable solid tumor malignancy with an activating FGFR mutation or translocation.Phase
Interventional
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Phase II pilot study of FOLFOXIRI plus panitumumab in metastatic RAS wild-type left-sided colorectal cancer
The purpose of this study is to evaluate the effectiveness (percent of patients with measurable response) of FOLFOXIRI and panitumumab for treatment of metastatic left ...Phase
Interventional
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A Phase II Basket Trial of Glutaminase Inhibitor (BeGIN) CB-839 HCl in Patients with NF1 Aberrations NF1 Mutant Malignant Peripheral Nerve Sheath Tumors (MPNST) KEAP1/NRF2 and LKB1 Aberrant Tumors
The purpose of the study is to determine the safety and tolerability of Glutaminase Inhibitor (BeGIN) CB-839 HCl in patients with NF1 mutant malignant peripheral ...Phase
Interventional
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A Phase II study of Concurrent Chemoradiation plus Durvalumab (MEDI4736) followed by Surgery followed by Adjuvant Durvalumab (MEDI4736) in medically operable patients with surgically resectable Stage III (N2) Non-Small Cell Lung Cancer: A Hoosier Cancer Research Network Clinical Trial LUN 17-321
The purpose of the study is to determine the safety and efficacy of having Durvalumab with concurrent chemoradiation followed by surgery in patients with surgically ...Phase
Interventional
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A Phase 2 Study of Savolitinib in Subjects with MET Amplified Metastatic Colorectal Cancer
The purpose of the study is to determine how well savolitinib works in treating patients with MET amplified colorectal cancer that has spread to other ...Phase
Interventional
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A randomized open-label multi-arm two-part phase II study to assess efficacy and safety of multiple LXH254 combinations in patients with previously treated unresectable or metastatic BRAFV600 or NRAS mutant melanoma
The purpose of the study is to evaluate whether LXH254 may help overcome intrinsic and acquired resistance to BRAF targeted therapy and whether it can ...Phase
Interventional
