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Randomized Phase 2 Trial of Ruxolitinib in Combination with Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma
This is a Phase 2 study testing a new treatment approach for newly diagnosed glioblastoma. It compares ruxolitinib plus radiation and temozolomide to the standard ...
Phase
Interventional
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A Phase 2 Open-label Study of VS-7375 an Oral KRAS G12D (ON/OFF) Inhibitor as Monotherapy and with Cetuximab in Patients with Metastatic KRAS G12D-Mutated Pancreatic Cancer (TARGET-D 201)
This is a Phase 2, open-label study for adults with metastatic pancreatic cancer that has a KRAS G12D gene mutation. The study is testing an ...
Phase
Interventional
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A PHASE II PROSPECTIVE TRIAL UTILIZING SHORT COURSE ANDROGEN DEPRIVATION THERAPY IN CONJUNCTION WITH ULTRA-HYPOFRACTIONATED SBRT FOR HIGH RISK NCCN PROSTATE CANCER WITH LOWER RISK ARTERA SCORES
This is a Phase 2 study for patients with high-risk prostate cancer who have Gleason scores of 8–10 or PSA levels between 20 and ...
Phase
Interventional
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A Multi-center Phase 2 Study of Hippocampal Avoidance in Craniospinal Irradiation for Leptomeningeal Metastases from Solid Tumors
This is a Phase 2 clinical study done at multiple hospitals that is testing a special type of radiation treatment called craniospinal irradiation (CSI) with ...
Phase
Interventional
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A PHASE II SINGLE-ARM SINGLE-CENTER STUDY EVALUATING TOXICITY OUTCOMES AND DOSIMETRY USING AN MR-GUIDED LINEAR ACCELERATOR FOR THE TREATMENT OF EARLY STAGE KIDNEY CANCER
This Phase II single arm study will prospectively enroll 30 patients. Patients have a simulation visit, where treatment planning includes an MRI scan to check ...Phase
Interventional
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A Phase 2 Randomized Blinded Placebo Controlled Trial Investigating the Efficacy and Safety of Visugromab plus Nivolumab with or without Docetaxel versus Docetaxel Monotherapy in Second Line Treatment of Participants with Metastatic Non Squamous Non Small Cell Lung Cancer (GDFATHER NSCLC 02)
This is a Phase 2 study testing the drug visugromab (a GDF-15 neutralizing antibody) in people with non-squamous non-small cell lung cancer (NSCLC) who are ...
Phase
Interventional
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A Phase 2 Open-label Study of VS-7375 an Oral KRAS G12D (ON/OFF) Inhibitor in Patients with Previously Treated Advanced KRAS G12D-Mutated Non-Small Cell Lung Cancer (TARGET-D 202)
This is a Phase II study for people with advanced non-small cell lung cancer (NSCLC) that has a specific genetic change called a KRAS G12D ...
Phase
Interventional
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A Phase II Study of the Interferon Gamma Inhibitor Emapalumab for Prophylaxis of Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome in Patients with Lymphoma and Multiple Myeloma Receiving Bispecific T-Cell Engagers.
This is a Phase 2, non-randomized study testing emapalumab, a medicine that blocks a protein called interferon gamma (IFN-y). The goal of this study is ...
Phase
Interventional
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Elacestrant in Advanced Triple Positive Breast Cancer a Phase II Evaluation (ELATE)
This is a Phase 2 study testing how well a combination of medicines work in treating people with triple-positive breast cancer. The study is open-label ...
Phase
Interventional
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Multicenter randomized phase II trial of neoadjuvant radioimmunotherapy versus chemoimmunotherapy in patients with clinical stages II-III (N2) non-small cell lung cancer (RICHIS)
This is a Phase 2 study for people with resectable non-small cell lung cancer (NSCLC) that is Stage IIA to Stage III. People with known ...
Phase
Interventional
