Displaying 66 (all) recruiting clinical trials.
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EXtending outcomes for PAncreas cancer patients with Nominal oligometastatic Disease (EXPAND): A randomized phase III trial
This is a study to determine whether, in patients with oligometastatic pancreatic ductal adenocarcinoma, metastasis-directed therapy to all sites of disease confers a benefit in ...Phase
Interventional
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A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas
This is a phase III study testing two treatments for patients with an advanced type of sarcoma called undifferentiated pleomorphic sarcoma and related sarcomas. One ...
Phase
Interventional
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A Phase 3 Double-blind Placebo-controlled Randomized Study to Assess the Efficacy and Safety of ASP3082 in Combination with mFOLFIRINOX or NALIRIFOX as First-line Treatment in Participants with KRAS G12D-mutated Metastatic Pancreatic Adenocarcinoma
This is a Phase 3 study testing a new drug called ASP3082 to see if it works well and is safe when combined with two ...
Phase
Interventional
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RANDOMIZED OPEN-LABEL STUDY OF THE BRIA-IMT REGIMEN AND CHECK POINT INHIBITOR VS PHYSICIAN'S CHOICE IN ADVANCED METASTATIC BREAST CANCER (BRIA-ABC)
This study is testing a new treatment called Bria-IMT (an experimental immunotherapy treatment) for patients with advanced breast cancer that has spread (metastatic) or come ...
Phase
Interventional
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A Phase III randomized multi-site open-label trial of BNT323/DB-1303 versus investigator s choice of chemotherapy in previously treated patients with HER2-expressing recurrent endometrial cancer (GOG 3105)
This is a Phase III study that is testing how well BNT323 works compared to a single chemotherapy drug chosen by the doctor. BNT323 is ...
Phase
Interventional
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A Phase 3 Randomized Open-label Multicenter Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment With or Without Bevacizumab Versus Standard of Care After Second-line Platinum-based Doublet Chemotherapy in Participants With Platinum-sensitive Recurrent Ovarian Cancer (TroFuse-022/ENGOT-ov84/GOG-3103)
This is a Phase 3 randomized (split into groups by chance) study designed to compare how well and how safely sacituzumab tirumotecan, with or without ...
Phase
Interventional
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A Phase 3 Randomized Open-label Multicenter Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab With or Without Bevacizumab Compared With Standard of Care as Firstline Maintenance Treatment for Participants With Persistent Recurrent or Newly Diagnosed Metastatic Cervical Cancer With PD-L1 CPS Greater Than or Equal to 1
This is a Phase 3 study testing a new experimental drug called sacituzumab tirumotecan (sac-TMT, also known as MK-2870) to see if it can help ...
Phase
Interventional
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FRAmework-01: A Two-Part Phase 3 Study of LY4170156 versus Chemotherapy or Mirvetuximab Soravtansine in Platinum-Resistant Ovarian Cancer and LY4170156 plus Bevacizumab versus Platinum-Based Chemotherapy plus Bevacizumab in Platinum-Sensitive Ovarian Cancer
This is a Phase 3 study testing a new medicine called LY4170156 (an investigational antibody-drug conjugate) targeting FRa for patients with advanced ovarian cancer whose ...
Phase
Interventional
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A Randomized Active-Controlled Double-blind Multicenter Phase 3 Clinical Study of Ivonescimab in Combination with FOLFOX versus Bevacizumab in Combination with FOLFOX for the First Line Treatment of Metastatic Colorectal Cancer
This is a Phase 3 study testing two different treatments for people with metastatic colorectal cancer (CRC) who have not yet received treatment for their ...
Phase
Interventional
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A Phase 3 Multicenter Open-label Randomized 2 Arm Study of Adjuvant Daraxonrasib versus Observation Following Curative Intent Therapy in Patients with Resected Pancreatic Ductal Adenocarcinoma (PDAC)
This is a Phase 3 study for patients with Pancreatic Ductal Adenocarcinoma (PDAC) whose cancer has been removed by surgery. The study is randomized and ...
Phase
Interventional
