Displaying 29 (all) recruiting clinical trials.
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Phase 1/2 Study of mRNA-4359 Administered Alone and in Combination with Immune Checkpoint Blockade in Participants with Advanced Solid Tumors
This is a Phase 1/2 study testing a new drug called mRNA-4359 in people who have solid tumors: a type of cancer that can ...
Phase
Interventional
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A Phase 1/2a Open-label Study of VS-7375 a KRAS G12D (ON/OFF) Inhibitor as Monotherapy and in Combination in Patients with Advanced KRAS G12D-Mutant Solid Tumors
VS-7375 is a highly selective oral, non-covalent, small molecule KRAS G12D inhibitor. VS-7375 demonstrated potent inhibition of KRAS G12D-mutated-dependent signal transduction and cancer cell viability ...Phase
Interventional
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ACNS1821: A Phase 1/2 Trial of Selinexor (KPT-330) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG)
This is a study testing a new medicine called Selinexor (small-molecule drug) in children and young adults who were recently diagnosed with a brain tumor ...
Phase
Interventional
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A Phase 1/2 Open-label Study of Oral S241656 (BDTX-4933) as Monotherapy and in Combination with Other Anti-Cancer Therapies in Patients with KRAS BRAF and Other Selected RAS/MAPK Mutation-Positive Malignancies
This is a Phase 1/2 study testing a new oral cancer drug called S241656 (BDTX-4933 - an investigational anti-cancer drug) in patients whose cancers have ...
Phase
Interventional
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Phase 1/2a Open-Label Clinical Trial Evaluating VBC101 An EGFR And CMet Targeted Bi-Specific Antibody Drug Conjugate In Participants with Advanced Solid Tumor Malignancies
This is a multicenter, open-label, multiple-dose, FIH Phase 1/2a trial to evaluate the safety and tolerability of VBC101 and To determine the MTD and ...Phase
Interventional
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A Phase 1a/1b Study of LY4052031 an Antibody-Drug Conjugate Targeting Nectin-4 in Participants with Advanced or Metastatic Urothelial Carcinoma or Other Solid Tumors
This is a Phase 1a/1b study testing a new drug called LY4052031 (an experimental cancer drug) in patients with advanced cancers, including bladder (urothelial ...
Phase
Interventional
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A PHASE Ib/II OPEN-LABEL MULTICENTER RANDOMIZED UMBRELLA STUDY EVALUATING THE EFFICACY AND SAFETY OF MULTIPLE TREATMENT COMBINATIONS IN PATIENTS WITH METASTATIC BREAST CANCER (MORPHEUS-panBC)
This is a Phase 1b/2 clinical study for people with metastatic (which is breast cancer that has spread to other parts of the body ...
Phase
Interventional
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HYPO2-BOOST GBM trial: Hypoxia-targeted radiotherapy boost for GBM
This is a Phase 1/2 study that will be testing whether a special MRI scan, called dynamic contrast-enhanced MRI (DSC-MRI), can help doctors find ...
Phase
Interventional
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A Modular Phase I/II Open-label Multicentre Study to Evaluate the Safety Tolerability and Efficacy of AZD3470 a PRMT5 Inhibitor as Monotherapy and in Combination With Anticancer Agent(s) in Participants With Relapsed/Refractory Haematologic Malignancies
This is a Phase I/II, open-label, multicentre clinical study that is testing AZD3470, an investigational oral medicine, in people with blood cancers (haematologic malignancies ...
Phase
Interventional
