Reducing Arrhythmia in Dialysis by Adjusting the Rx Electrolytes- RADAR

Brief description of study

The purpose of this study is to evaluate heart rhythms in patients who are being treated with hemodialysis. This research will see how these heart rhythms are affected with changes in the dialysis ultrafiltration rate. An implantable cardiac monitor called the Reveal LINQ will be used to track heart rhythm. The research has 2 related, randomized cross-over trials; Study A- dialysate interventions trial and Study B-ultrafiltration rate intervention trial. Study A- dialysate interventions trial will find out if changing the dialysate (dialysis bath prescription) of potassium and bicarbonate can better help the heart rhythms in people with kidney failure who are being treated with chronic hemodialysis. We want to closely watch the effect that these dialysate changes have on your heart rhythm. We also want to find out if changing the dialysate is safe to do without causing too many side effects. Study B-ultrafiltration rate intervention trial find out if changing the dialysis ultrafiltration rate (UFR) can better help the heart rhythms of people with kidney failure who are being treated with chronic hemodialysis. The ultrafiltration rate controls how much fluid is removed from the body during dialysis treatments. We want to closely watch the effect that these ultrafiltration rate changes have on your heart rhythm and fluid status. We also want to find out if changing the UFR is safe to do without causing too many side effects.


Clinical Study Identifier: s18-01324
ClinicalTrials.gov Identifier: NCT03519347
Principal Investigator: David Michael Charytan.


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