Leveraging Biomarkers for Personalized Treatment of Alcohol Use Disorder Comorbid With PTSD

Brief description of study

The purpose of this research study is to see the short-term and long-term effects of topiramate on alcohol dependence comorbid (co-occurring) with post-traumatic stress disorder (PTSD). To assess whether topiramate is a safe and feasible treatment for alcohol dependence comorbid with PTSD, the effects of topiramate and specific genes on alcohol dependence, measurements of brain responses to stimulation of specific brain areas, and comparisons of blood markers and brain markers to determine differences in blood markers/brain markers in those taking topiramate versus those taking placebo. The use of topiramate in this study is investigational because topiramate is not FDA-approved to treat alcohol dependence comorbid with PTSD.

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Clinical Study Identifier: s18-01405
ClinicalTrials.gov Identifier: NCT03667846
Principal Investigator: Charles R. Marmar.


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