Vancomycin Powder and Dilute Povidone Iodine Lavage for Infection Prophylaxis in High Risk Total Joint Arthroplasty: A Randomized Prospective Trial

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Osteoarthritis
  • Age: Between 18 - 100 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Subjects have signed the Informed Consent Form (ICF) prior to any trial related procedures.
    2. Subjects have no open wounds on operative leg
    3. Subjects are scheduled to undergo elective primary and revision total joint arthroplasty for posttraumatic, osteoarthritis, avascular necrosis, and/or inflammatory arthritis
    4. Subjects do not have active infection on the operative leg, the operative joint
    5. Subjects are identified as high risk for the development of PJI which is determined by the presence of one or more of the following characteristics: BMI >35, active smoker, ASA = 3, immunosuppressed (i.e. being treated with chemotherapy, diagnosis of HIV, diagnosis of HCV, being treated with chronic steroids, patients with inflammatory arteriopathies), diagnosis with diabetes mellitus, established colonization with S. aureus, or any patient undergoing revision TJA
    6. Subjects understand the risks and benefits associated with TJA and willing to cooperate and follow study protocol and visit schedule

You may not be eligible for this study if the following are true:

    1. Subjects have psychiatric disorder that precludes safe study participation or that necessitates confinement in a custodial environment at home or in a chronic care facility
    2. Subjects does not have the mental capacity to participate and comply with the study protocol
    3. Subjects have active infections in the operative leg/joint
    4. Subjects have severe dementia
    5. Subjects who have suspicion of illicit drug abuse by patient
    6. Subjects are pregnant or breastfeeding
    7. Subjects are unable to provide written consent
    8. Subjects with ASA score of 5 & 6
    9. Subjects with history of prior native septic joint arthritis
    10. Subjects who have no planned procedure within 90 days of surgery
    11. Subjects with known allergy to vancoycin



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