Comparing pain related outcomes in patients who receive TXA alone and in combination with tourniquet in total knee arthroplasty.

Brief description of study

The purpose of this study is to determine whether a tourniquet is necessary during total knee replacement surgery. Total joint arthroplasty (TJA) is one of the most common operations performed in the United States annually, however, blood loss is one of the major problems following total knee replacement. Thus, as a routine practice, many surgeons apply a tourniquet during total knee replacement to reduce blood loss. However, numerous disadvantages of tourniquet use have been reported, including reduced early knee flexibility, increased pain, increased postoperative leg swelling, and more frequent wound complications. This study aims to assess the pain level after surgery including the amount of pain medication used. The study team will analyze the risks and benefits of each method (with and without tourniquet) to determine which group has the lowest level of pain and complications.


Clinical Study Identifier: s18-00638
Principal Investigator: Ran R Schwarzkopf.


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