Identifying neural mechanisms of PTSD symptom reduction induced by combined estrogen and prolonged exposure therapy.

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Ptsd
  • Age: Between 18 - 45 Years
  • Gender: Female
  • Other Inclusion Criteria:
    1. Female, 18-45 years of age
    2. Chronic (at least one month post-trauma) DSM-5 PTSD symptoms
    3. CAPS-5 Past Month score = 26
    4. Criterion A traumatic event
    5. Stable medications for 3 or more months by the time of study entrance (with the exception of benzodiazepines)
    6. Women on oral contraceptives, specifically those using monophasic or biphasic of first, second, third or fourth generation with up to 35mcg of ethinyl estradiol; OR using etonogestrel / ethinyl estradiol 0.120mg/0.015mg per day vaginal ring birth control; OR using the norelgestromin / ethinyl estradiol 0.150mg/0.035mg per day transdermal patch birth control
    7. Willing and able to provide informed consent

You may not be eligible for this study if the following are true:

    1. Diagnosis of bipolar I disorder with a past year manic episode
    2. Diagnosis of a psychotic disorder or psychotic symptoms that would interfere with the ability to focus on posttraumatic stress disorder (PTSD) in clinic, as determined by clinical judgment
    3. Diagnosis of moderate or severe substance use disorder that would interfere with the ability to focus on posttraumatic stress disorder (PTSD) in clinic, as determined by clinical judgment
    4. Cognitive impairment that would interfere with the ability to focus on posttraumatic stress disorder (PTSD) in clinic, as determined by clinical judgment
    5. History of neurological disease (that involves the brain), seizure, or significant head trauma (i.e., extended loss of consciousness, neurological sequelae, or known structural brain lesion)
    6. Suicidal ideation with imminent risk that warrants a higher level of care
    7. Concurrent trauma focused psychotherapy
    8. Pregnancy (to be ruled out by urine ß-HCG).
    9. Metallic implants or devices contraindicating magnetic resonance imaging by interfering with patient safety or fMRI data collection. Cases will be cleared by the Principal Investigator and Center for Brain Imaging
    10. History of breast cancer or hormone-responsive cancer.
    11. Use of benzodiazepines
    12. Self-injurious behavior that involves suicidal intent, requires medical attention, or occurs daily



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