FLOW - Effect of semaglutide versus placebo on the progression of renal impairment in subjects with type 2 diabetes and chronic kidney disease

Brief description of study

Having type 2 diabetes can cause many different health problems, for example chronic kidney disease. When you have chronic kidney disease caused by type 2 diabetes, this is called ‘diabetic kidney disease’. Diabetic kidney disease will grow and become worse over several years. A completed study showed that a medicine called semaglutide might slow down the growth and worsening of diabetic kidney disease. The purpose of this study is to look at how well semaglutide can treat chronic kidney disease in people with type 2 diabetes compared to a ‘dummy medicine’ called a placebo. The placebo looks just like semaglutide but contains no medicine and has no effect on the body. A placebo is used in research studies to compare the results and side effects of the drug being studied to the results and side effects of taking no medication. This allows us to see if the drug being studied works and what side effects it causes. Semaglutide is an FDA approved medication for diabetes type 2. However, it is not approved to treat kidney disease. For this reason, its use in this study is considered experimental


Clinical Study Identifier: s19-00335
ClinicalTrials.gov Identifier: NCT03819153


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