WUH: Impact of medical and surgical weight loss on lipocalin prostaglandin D2 synthase (LPGDS) and bile acid levels.

Brief description of study

Obesity and type 2 diabetes are medical conditions that are associated with significant health risks. These include stroke, heart disease, and kidney disease. Medical research has been attempting to identify new ways to treat both of these diseases. What clinicians have recently noticed, is the impact of a low calorie diet and weight loss surgery appears to have a profound beneficial role on both obesity and type 2 diabetes. However, the mechanism of how this is achieved remains unclear. This study will attempt to study various proteins and hormone levels that may become altered with dietary restriction and weight loss surgery. Specifically, the research laboratory has studied and identified a protein known as “Lipocalin Prostaglandin D2 Synthase.” It appears to be associated with both obesity and type 2 diabetes. This protein and various others will be examined to better understand their biologic roles.

Clinical Study Identifier: s18-01701
Principal Investigator: Raymond Lau.

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