Microbial and human biomarkers of thoracic disease after lung transplantation

Brief description of study

We will prospectively collect airway and blood samples on 200 subjects undergoing lung transplantation. We will evaluate airway microbial signatures associated with local (lower airway) and systemic (blood) immune tone. We will then study whether host or transplant related factors affect microbiota and/or host signatures (Aim 1) and whether these signatures predict subjects’ longitudinal development of lung dysfunction and chronic lung allograft dysfunction (CLAD, Aim 2).

Clinical Study Identifier: s19-01723

Principal Investigator: Leopoldo N. Segal.

Other Investigators: Marlena Habal, Jamie L. Bessich, Samaan Rafeq, Darya Rudym, Stephanie H. Chang, Sheik Mohammad Imran Sulaiman, Mandana Mahmoudi, Massimo Mangiola, Matthias C. Kugler, Luis F. Angel.

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Clinical Research Studies