WUH: Characterization of microsomal triglyceride transfer protein (MTP) in metabolic and gastrointestinal tissue in obese and other subjects undergoing therapeutic surgeries.

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WUH: Characterization of microsomal triglyceride transfer protein (MTP) in metabolic and gastrointestinal tissue in obese and other subjects undergoing therapeutic surgeries.

Brief description of study

Microsomal triglyceride transfer protein (MTP) is an enzyme that is responsible for fat and cholesterol metabolism. Blocking the effect of MTP may be helpful in decreasing heart disease risk. However, it is unknown how much MTP may contribute to obesity. The purpose of this study is to study the effect of how weight may affect MTP and related molecules in different tissue types. This study will collect samples of pancreas, liver, adipose (fat) (deep and superficial), blood, blood vessel tissue, cardiac (heart) tissue, pericardial (membrane surrounding heart) tissue, and gastrointestinal tissue from people undergo an intra-abdominal or intra- thoracic surgery or undergoing an endoscopic procedure.

Clinical Study Identifier: s18-01703

Principal Investigator: Raymond Lau.

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