A Multicenter Adaptive Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Coronavirus Infection, Unspecified Site
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Age: Between 18 - 110 Years
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Gender: Male or Female
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Other Inclusion Criteria:
- Subjects who are admitted to a hospital with symptoms suggestive of COVID-19 infection.
- Subjects (or legally authorized representatives) able to provide written informed consent prior to initiation of any study procedures
- Subjects who understand and agree to comply with planned study procedures.
- Subjects who agree to the collection of oropharyngeal (OP) swabs.
- Subjects =18 years of age at time of enrollment.
- Subjects who have laboratory-confirmed SARS-CoV-2 infection as determined by PCR or other commercial or public health assay in any specimen collected <72 hours prior to randomization
- Subjects with illness of any duration, and at least one of the following:
- Radiographic infiltrates by imaging (chest x-ray, CT scan, etc.), OR
- Clinical assessment (evidence of rales/crackles on exam) AND SpO2 = 94% on room air, OR
- Requiring supplemental oxygen, OR
- Requiring mechanical ventilation
- Women of childbearing potential must agree to either abstinence or use at least one primary form of contraception for the duration of the study
- Subjects agree to not participate in another clinical trial for the treatment of COVID-19 or SARS-CoV-2 through Day 29
You may not be eligible for this study if the following are true:
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- Subjects with ALT/AST >5 times the upper limit of normal.
- Subjects with estimated glomerular filtration rate (eGFR) < 50 or requiring dialysis.
- Subjects who are pregnant or breast feeding.
- Subjects who are anticipating transfer to another hospital which is not a study site within 72 hours
- Subjects allergic to any study medication.
If you are registered as a volunteer, please login to the dashboard to send referrals.