Off label study to evaluate the efficacy of Hydroxychloroquine for pre-exposure prophylaxis (PrEP) to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among Health Care Workers who are high Risk of Occupational Exposure to SARS-CoV-2 | NYU Langone Health

Off label study to evaluate the efficacy of Hydroxychloroquine for pre-exposure prophylaxis (PrEP) to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among Health Care Workers who are high Risk of Occupational Exposure to SARS-CoV-2

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

Conditions:
Covid-19
Age: Between 18 years - 100 years
Gender: Male or Female

Other Inclusion Criteria:
Inclusion Criteria for Group A and B:
1. Subjects who are =18 years NYULH health care worker who meets one of the following criteria:
  - Involved in an aerosol generating procedure (nasopharyngeal specimen collection, tracheal intubation, nebulizer treatment, open airway suctioning, collection of sputum, tracheostomy, bronchoscopy, CPR) on a confirmed COVID-19 patient while wearing Personal Protective Equipment (PPE)
  - Direct bedside care of confirmed COVID-19 patient while wearing Personal Protective Equipment (PPE) for 3 or more shifts in a 7 day period
  - Direct care of persons under investigation (PUIs) in the ED or other inpatient unit while wearing Personal Protective Equipment (PPE) for 3 or more shifts in a 7 day period
2. Subjects who are willing and able to provide informed consent

You may not be eligible for this study if the following are true:

Exclusion Criteria for Group A only:
1. Subjects with known hypersensitivity to hydroxychloroquine or chloroquine
2. Subjects with known diagnosis of COVID-19
3. Subjects who have concomitant use of:
  - amiodarone
  - digoxin
  - flecainide
  - procainamide
  - propafenone
4. Subjects who has history of Torsades de pontes
5. Subjects who has history of retinal disease
6. Subjects with known chronic kidney disease = stage 4
7. Subjects who have congenital prolonged QTc interval syndrome (Jervell and Lange-Nielsen syndrome, Romano-Ward syndrome)