A Multicenter Randomized Controlled Trial on Safety and Efficacy of Hydroxychloroquine for the Treatment of COVID-19 in Hospitalized Adults and Children
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Covid-19
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Age: Between 0 - 110 Years
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Gender: Male or Female
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Other Inclusion Criteria:
- Subjects who are hospitalized with symptoms consistent with COVID-19 including but not limited to any of the following: fever (documented or subjective), cough, dyspnea, diarrhea, nausea, diffuse myalgias, and/or anosmia
- Subjects must provide signed informed consent
- Subjects who need ECMO as determined by NYU Langone ECMO team
- Subjects must have positive SARS-CoV-2 RT-PCR testing (nasopharyngeal, oropharyngeal, sputum and/or bronchoalveolar lavage) done up to =72 hours prior to informed consent and conducted onsite or in external laboratory certified by NY State to conduct SARS-CoV-2 testing
You may not be eligible for this study if the following are true:
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- Subjects who are admitted to the ICU or need the use of a mechanical ventilation, ECMO, non-rebreather oxygen supplementation or vasopressor at time of randomization
- Treated with CQ or HCQ within the 30 days before the start of the study drug treatment
- Subjects who are participating in a clinical trial investigating a non-FDA approved drug with the intent to treat SARS-CoV-2 within 30 days prior to the start of the study drug
- Subjects who are unable to take oral medication
- History of allergic reaction or intolerance to CQ or HCQ
- Those with the baseline corrected qT interval >470 milliseconds (male) or >480 milliseconds (female), history of congenital qT prolongation, and/or history of cardiac arrest.
- Subjects with concomitant therapy with flecainide, amiodarone, digoxin, procainamide, propafenone, thioridazine, or pimozide
- Has history of retinal disease including a documented history of diabetic retinopathy
- Subjects with known history of G6PD deficiency in the blood
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.