Efficacy of Hydroxychloroquine for Post-exposure Prophylaxis (PEP) to Prevent Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection Among Adults Exposed to Coronavirus Disease (COVID-19): a Blinded Randomized Study
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Healthy People Who Were In Contact With Covid-9 Positive Person
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Age: Between 18 years - 80 years
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Gender: Male or Female
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Other Inclusion Criteria:
- Subjects who are willing and able to provide informed consent
- Subjects who dad a close contact of a person with known PCR-confirmed SARS-CoV-2 infection or who is currently being assessed for COVID-19. Close contact defined as:
- Household contact
- Medical staff, first responders, or other care persons who cared for the person without personal protection
- Subjects had less than 4 days since last contact with a person with SARS-CoV-2 infection
- Subjects with body weight < 100 kg
- Subjects who had access to device and internet for Telehealth visits
You may not be eligible for this study if the following are true:
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- Subjects with known hypersensitivity to HCQ or other 4-aminoquinoline compounds
- Subjects currently hospitalized
- Subjects with symptomatic with subjective fever, cough, or sore throat
- Current medications exclude concomitant use of HCQ
- Concomitant use of other anti-malarial treatment or chemoprophylaxis
- Subjects with history of retinopathy of any etiology
- Those who have psoriasis
- Those who have porphyria
- Subjects with known bone marrow disorders with significant neutropenia
- Concomitant use of digoxin, cyclosporin, cimetidine, or tamoxifen
- Subjects with known liver disease
- Subjects with known long QT syndrome
- Subjects who use any investigational or non-registered drug or vaccine within 30 days preceding the first dose of the study drugs, or planned use during the study period
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.