Clinical Research Studies

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Hiv
• Age: Between 18 Year(s) - 100 Year(s)
• Gender: Male or Female

• Other Inclusion Criteria:
  

  Living Donors:

  1. Participants are between 18 and 100 years of age
  2. HIV-specific factors for eligibility:
     • CD4+ T Cell count = 500/µL for 6 months prior to evaluation
     • HIV-1 RNA < 50 copies RNA/mL
     • No evidence of renal disease prior to evaluation
     • Cleared for donor evaluation by living donor intake team

  Recipients:

  1. Participant who are between 18 and 100 years of age
  2. Evaluated and cleaned by Transplant Infectious Disease
  3. Demonstrated adherence to a stable ART regimen for = 6 months
  4. Demonstrated compliance with medical care and dialysis (if applicable) for = 6 months
  5. CD4+ T-cell counts = 200 cells per cubic millimeter while on stable ART therapy for a minimum of 16 weeks.
  6. Undetectable HIV type 1 (HIV-1) RNA levels (by RT-PCR)
  7. Participants with opportunistic infections while on stable ART
  8. If HBV or HCV co-infected:
     • HBV:Absence of HBSAg and Hepatitis B viremia (by PCR)
     • HCV:SVR-24 (undetectable PCR for 24 weeks)
     • Liver biopsy or FibroScan demonstrating fibrosis stage 3 or less
     • Absence of significant portal hypertension
     • Evaluation and clearance by Transplant Hepatology
  9. A completed HIV Resistance DNA GenoSure Archive Assay

  
  

You may not be eligible for this study if the following are true:

• Living Donors:

  1. Subjects with history of any of the following conditions:
     • Progressive Multifocal leukoencephalopathy (PML)
     • Cryptosporidiosis, chronic intestinal
     • Coccidiomycosis
     • Pulmonary aspergillosis
     • Lymphoma
     • Non-cutaneous Kaposi’s sarcoma
  2. Human papilloma virus (HPV) associated cervical or anal disease including CIN/AIN III and carcinoma in situ
  3. Non-adherence with ART in preceding 6 months
  4. Subjects with persistent viremia despite appropriate ART
  5. Subjects with CD4+ T-cell counts <500 cells per cubic millimeter while on stable ART for a minimum of 6 months prior to donation
  6. Subjects with influenza or RSV infection within preceding 30 days

  Recipients:

  1. Subjects with history of any of the following conditions:
     • Progressive Multifocal leukoencephalopathy (PML)
     • Cryptosporidiosis, chronic intestinal
     • Coccidiomycosis
     • Pulmonary aspergillosis
     • Lymphoma
     • Non-cutaneous Kaposi’s sarcoma
  2. Human papilloma virus (HPV) associated cervical or anal disease including CIN/AIN III and carcinoma in situ
  3. Non-adherence with ART in preceding 6 months
  4. Subjects with persistent viremia despite appropriate ART
  5. Subjects with CD4+ T-cell counts < 200 cells per cubic millimeter while on stable ART for a minimum of 16 weeks
  6. Subjects with influenza or RSV infection within preceding 30 days
  7. Subjects who have an incomplete HIV Resistance DNA GenoSure Archive result