Recombinant tPA by Endovascular Administration for the treatment of Submassive pulmonary embolism using pharmaco-mechanical Catheter directed thrombolysis for the reduction of thrombus burden (RESCUE study)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Pulmonary Embolism
  • Age: Between 18 - 99 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Participants who are willing and able to provide informed consent
    2. Participants with Pulmonary embolism (PE) symptom duration = 14 days
    3. Those who have filling defect in at least one main or lobar pulmonary artery as determined by Computerized tomography angiography (CTA)
    4. Right ventricular/left ventricular (RV/LV) diameter ratio = 0.9 by CTA
    5. Participants willing and able to comply with all study procedures and follow-up

You may not be eligible for this study if the following are true:

    1. Participants with Cerebrovascular accident (CVA) or Transient ischemic attack (TIA) within one (1) year
    2. Participants with head trauma, active intracranial, or intraspinal disease = one (1) year prior to inclusion in the study
    3. Has active bleeding from a major organ within one (1) month prior to inclusion in the study
    4. Has intracranial condition(s) that may increase the risk of bleeding
    5. Participants with bleeding diatheses
    6. Clinician deems high-risk for catastrophic bleeding
    7. History of heparin-induced thrombocytopenia (HIT Syndrome)
    8. Participants who are pregnant
    9. Those on any vasopressor support
    10. Participants who have cardiac arrest during this hospitalization
    11. Had evidence of irreversible neurological compromise
    12. Those with life expectancy < one (1) year
    13. Profound bradycardia requiring a temporary pacemaker and/or inotropic support



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