Anticoagulation for Stroke Prevention and Recovery after ICH (ASPIRE)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Hemorrhagic Stroke
  • Age: Between 18 - 105 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Participants with intracerebral hemorrhage
    2. Participants with non-valvular AF (defined as atrial fibrillation or atrial flutter), documented by electrocardiography or a physician-confirmed history of prior AF
    3. Able to provide written informed consent
    4. Able to comply with all study procedures and available for duration of the study
    5. For females of reproductive potential: use of highly effective contraception

You may not be eligible for this study if the following are true:

    1. Participants with history of ICH before index event
    2. Those with zctive infective endocarditis
    3. Participants with lobar ICH with cerebral amyloid angiopathy
    4. Those using anticoagulant drugs or antiplatelet drugs
    5. Participants who have previous or planned left atrial appendage closure
    6. Has clinically significant bleeding diathesis
    7. Active hepatitis or hepatic insufficiency
    8. Anemia (hemoglobin <8 g/dL) or thrombocytopenia (<100 x 109/L) that is chronic in the judgment of the investigator
    9. Life expectancy <1 year
    10. Participants who are pregnant or breastfeeding
    11. Has known allergy to aspirin or apixaban
    12. Participants who are currently in another clinical trial
    13. Unwilling to discontinue prohibited medications



If you are registered as a volunteer, please log in to contact the study team/express interest in this study.

Contact the research team to learn more about this study.

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