BARCONA Trial: A Randomized Trial of Bardoxolone Methyl in Patients Infected with SARS-Corona Virus-2 (COVID-19)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
  • Age: Between 18 - 100 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Laboratory-confirmed COVID-19 infection as determined by polymerase chain reaction (PCR)
    2. Hospitalized patients who meet one of the following conditions:
      • Radiographic infiltrates by imaging (chest x-ray, CT scan, etc.); OR
      • At rest, blood oxygen saturation = 94%; OR
      • Require supplemental oxygen; OR
      • Requiring non-invasive ventilation; OR
      • Requiring invasive mechanical ventilation for up to 2 days.
    3. Participant or legally authorized representative is willing to give informed consent

You may not be eligible for this study if the following are true:

    1. Intubated and on invasive mechanical ventilation for three or more days at the time of randomization
    2. Known left ventricular ejection fraction (LVEF) <40% or prior hospitalization for heart failure
    3. Cardiac arrest
    4. Shock
    5. Uncontrolled bacterial, fungal, or non-COVID viral infection
    6. eGFR <30 ml/min/1.73 m2 or requiring dialysis
    7. ALT or AST > 5X ULN
    8. History of cirrhosis, chronic active hepatitis or severe hepatic disease
    9. Pregnant or lactating women
    10. Enrolled in other trial of unapproved therapies, unless approved by trial Principal Investigator. In general, co-enrollment will be permitted unless there are safety concerns, mechanistic incompatibility or inability to adjudicate serious adverse events and will be decided on a case by case basis.
    11. If in the opinion of the clinical team, progression to death is imminent and inevitable within the next 24 hours, irrespective of the provision of treatments

If you are registered as a volunteer, please login to the dashboard to send referrals.

Contact the research team to learn more about this study.

By clicking "Contact Research Team", your contact information will be sent securely to the research staff associated with the study. You will also receive a copy of this email in your inbox, as well as other notifications to determine your participation status in the study.