Locus-coeruleus function in normal elderly and AD risk (LEAD)

Brief description of study

(S,S)-[11C]Methylreboxetine ((S,S)-[11C]MRB) is a radioligand developed for positron emission tomography (PET) imaging of the brain adrenergic receptors. In ongoing clinical studies, 11C-MRB PET is currently being examined to determine whether the tracer has utility in the differential diagnosis and follow-up of Alzheimer’s disease risk and in evaluating the efficacy of preventive therapies. To enable the continued use of 11C-MRB and to confirm safety, it is important to determine the radiation exposure caused by such studies. The use of this tracer has been approved by the FDA since 2005. This tracer has been used for PET imaging of over 500 human studies with no major side effects. Before this tracer can be used in our main study, the dosimetry results need to be analyzed and reported locally prior to the start of the study.

Clinical Study Identifier: s20-00002 Identifier: NCT04403165
Principal Investigator: Ricardo Miguel Osorio Suarez.
Other Investigators: Shai Porat, Yu-Shin Ding.

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