A Phase III Randomized Double-blind Placebo-controlled Multicenter Study in Adults to Determine the Safety Efficacy and Immunogenicity of AZD1222 a Non-replicating ChAdOx1 Vector Vaccine for the Prevention of COVID-19

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A Phase III Randomized Double-blind Placebo-controlled Multicenter Study in Adults to Determine the Safety Efficacy and Immunogenicity of AZD1222 a Non-replicating ChAdOx1 Vector Vaccine for the Prevention of COVID-19

Brief description of study

The aim of the study is to assess the safety, efficacy, and immunogenicity of AZD1222 for the prevention of COVID-19. The COVID-19 pandemic has caused major disruption to healthcare systems with significant socioeconomic impacts. Currently, there are no specific treatments available against COVID-19 and accelerated vaccine development is urgently needed. A safe and effective vaccine for COVID-19 prevention would have significant public health impact.

Clinical Study Identifier: s20-01219

ClinicalTrials.gov Identifier: NCT04516746

Principal Investigator: Mark J. Mulligan.

Other Investigators: Steven E Carsons, Rebecca Boas, Angelica Cifuentes Kottkamp, Natella Aronova, Jennifer Lee Dong, Janette Hernandez Torres, Vijaya Soma, Theresa Monahan Fiorito, Melinda Katz, Miloni Haresh Thakker, Asif Noor, Jennifer Nierman Knishinsky, Kevin Douglas Zhang, Adam Schwartz, Lars Anders David Green, Sabrina E Felson, Lois Anne Katz, Dinuli Hashangani Delpachitra, Reny Jose, Ellie R. Carmody, Claudia Patricia De La Matta Rodriguez, Celia Engelson, Sigridh A Munoz-Gomez, Sajumon K Joseph, Andrew Banks Fleming, Ramin Herati, Stephanie Sterling, Daniel Sartori, Urmee Saha, Martin Backer, Robert James Ulrich, Alexander Mcmeeking, Diana Badillo, Jose O. Aleman, Melanie R Jay, Adina Claudia Musta, Diane H Johnson, Reza P Parungao, Kavita R Kumar, Tamia Davis, Lalitha Parameswaran, Benjamin J Eckhardt, Jay Pendse.

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