A Phase III Randomized Double-blind Placebo-controlled Multicenter Study in Adults to Determine the Safety Efficacy and Immunogenicity of AZD1222 a Non-replicating ChAdOx1 Vector Vaccine for the Prevention of COVID-19

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A Phase III Randomized Double-blind Placebo-controlled Multicenter Study in Adults to Determine the Safety Efficacy and Immunogenicity of AZD1222 a Non-replicating ChAdOx1 Vector Vaccine for the Prevention of COVID-19

Brief description of study

The aim of the study is to assess the safety, efficacy, and immunogenicity of AZD1222 for the prevention of COVID-19. The COVID-19 pandemic has caused major disruption to healthcare systems with significant socioeconomic impacts. Currently, there are no specific treatments available against COVID-19 and accelerated vaccine development is urgently needed. A safe and effective vaccine for COVID-19 prevention would have significant public health impact.

Clinical Study Identifier: s20-01219

ClinicalTrials.gov Identifier: NCT04516746

Principal Investigator: Mark J. Mulligan.

Other Investigators: Sajumon K Joseph, Ramin Herati, Andrew Banks Fleming, Lalitha Parameswaran, Alexander Mcmeeking, Stephanie Sterling, Daniel Sartori, Sigridh A Munoz-Gomez, Celia Engelson, Claudia Patricia De La Matta Rodriguez, Ellie R. Carmody, Reny Jose, Dinuli Hashangani Delpachitra, Lois Anne Katz, Sabrina E Felson, Lars Anders David Green, Adam Schwartz, Kevin Douglas Zhang, Jennifer Nierman Knishinsky, Asif Noor, Miloni Haresh Thakker, Melinda Katz, Theresa Monahan Fiorito, Vijaya Soma, Steven E Carsons, Angelica Cifuentes Kottkamp, Rebecca Boas, Janette Hernandez Torres, Diane H Johnson, Reza P Parungao, Kavita R Kumar, Jennifer Lee Dong, Tamia Davis, Benjamin J Eckhardt, Jay Pendse, Urmee Saha, Martin Backer, Robert James Ulrich, Diana Badillo, Natella Aronova, Jose O. Aleman, Melanie R Jay, Adina Claudia Musta.

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