Mesenchymal Stem Cells for the Treatment of Moderate to Severe COVID-19 Acute Respiratory Distress Syndrome
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Covid-19
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Age: Between 18 - 100 Years
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Gender: Male or Female
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Other Inclusion Criteria:
- Participants who are 18 years or older
- Patient has coronavirus disease COVID-19
- Participants requiring mechanical ventilatory support with moderate to severe ARDS
- Participants with laboratory results of high sensitivity C-Reactive Protein (hs-CRP) serum level >4.0 mg/dL
- Participants with Acute Physiologic and Chronic Health Evaluation (APACHE IV) score >5
- Participant or his/her legally authorized representative (LAR) is able to provide written informed consent
- Creatinine clearance less than 30 mL/minute
- LFTs (ALT or AST) > 5x normal
You may not be eligible for this study if the following are true:
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- Currently receiving extracorporeal membrane oxygenation (ECMO) or high frequency oscillatory ventilation (HFOV)
- Pregnant or lactating
- Participants with established positive bacterial blood cultures prior to enrollment or suspicion of superimposed bacterial pneumonia
- Those with untreated HIV infection
- Participants who have been intubated for more than 72 hours
- Known hypersensitivity to DMSO or to porcine or bovine proteins
- History of prior respiratory disease with requirement for supplemental oxygen
- Any end-stage organ disease which in the opinion of the investigator may possibly affect the safety of remestemcel-L treatment
- Receiving an investigational cellular therapy agent
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.