An Observational Longitudinal Oligo-Center Study to Define Clinical Biofluid Imaging and Digital Outcome Measures in Multiple System Atrophy

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Multiple System Atrophy
  • Age: Between 40 - 80 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Participants who are able to understand the purpose and risks of the study and provide written informed consent
    2. Participants who have diagnosis of probable or possible multiple system atrophy (MSA-P or MSA-C) according to current consensus diagnostic criteria
    3. Aged 40-80 with anticipated survival of at least 3 years (in the opinion of the Investigator)
    4. Those with a modified UMSARS-1 score of 17 or below
    5. Participants who are willing and able to participate in all the study procedures
    6. Ability to tolerate and no contraindications for brain MRI.
    7. Ability to tolerate and no contraindications for CSF collection.

You may not be eligible for this study if the following are true:

    1. Presence of supranuclear gaze palsy
    2. Presence of cognitive dysfunction
    3. Those who are severe-to-complete dependence on caregivers (score 4 on UMSARS-4), severe impairment of swallowing (score =3 on UMSARS-1, Question 2), or very frequent falls (score =3 on UMSARS-1, Question 8) based on scores
    4. Family history or a known genetic cause of ataxia or parkinsonism
    5. Hallucinations not induced by drugs
    6. Unstable psychiatric illness, including psychosis, suicidal ideation, or untreated major depression
    7. History or baseline MRI results showing evidence of structural abnormalities
    8. Any contraindications to having a brain MRI
    9. Transient ischemic attack or stroke, or any unexplained loss of consciousness
    10. History of any brain surgery for MSA
    11. History of human immunodeficiency virus or hepatitis C virus antibody
    12. Chronic, recurrent, or serious infection
    13. History of unstable angina, myocardial infarction, chronic heart failure
    14. History of, or ongoing, malignant disease
    15. Any condition which may interfere with completing the procedures or unable to provide written informed consent in the opinion of the investigator



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