Feasibility and Safety of Geniculate Artery Embolization for Treatment of Mild to Moderate Knee Osteoarthritis

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Osteoarthritis
  • Age: Between 30 - 75 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Participants who are 30-75 years of age of any gender
    2. Kellgren-Lawrence Grade 2, or 3 knee OA on most recent knee radiograph obtained within 6 months of screening visit
    3. Participants with knee pain resistant to conservative treatment for at least 3 months
    4. Participants with moderate to severe knee pain
    5. Willing, able, and mentally competent to provide informed consent and complete study questionnaires in English. The Study questionnaire is validated in English.

You may not be eligible for this study if the following are true:

    1. Active systemic or local knee infection
    2. Active malignancy
    3. Life expectancy less than 12 months
    4. Prior ipsilateral knee surgery excluding arthroscopic surgery more than 6 months ago
    5. Ipsilateral knee intra-articular injection in the last 3 month
    6. Participants with rheumatoid arthritis, spondyloarthropathies, crystal disease, gout, pseudogout, or lupus
    7. Pregnant
    8. Participants with renal dysfunction
    9. Body weight greater than 200 Kg
    10. Uncorrectable coagulopathy (condition in which the blood's ability to clot is impaired)
    11. Known history of contrast allergy resulting in anaphylaxis
    12. Known significant arterial atherosclerosis that would limit selective angiography and/or lower extremity symptoms thought to be secondary to arterial vascular disease
    13. Post-traumatic knee
    14. known avascular necrosis in the target knee
    15. Participants with contraindications to MRI such as such as claustrophobia, metallic fragment/implants, pacemaker



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