The use of cannabidiol (CBD) in pain reduction and opioid use after shoulder arthroscopy: A Double-Blind Randomized Control Study
Are you eligible to participate in this study?
You may be eligible for this study if you meet the following criteria:
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Conditions: Shoulder Arthroscopy
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Age: Between 18 years - 75 years
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Gender: Male or Female
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Other Inclusion Criteria:
- Subject undergoing an arthroscopic shoulder procedure (rotator cuff repair, decompression, labrum repair)
- Subject ages 18-75, willing and able to give written informed consent and comply with the requirements of this Clinical Investigation Plan
- Female subjects must be currently practicing effective forms of two types of birth control, which are defined as those, alone or in combination, that result in a low failure rate (less than 1% per year) when used consistently and correctly
- Male subjects must be using an effective form of contraception
You may not be eligible for this study if the following are true:
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- Legally incompetent or mentally impaired
- Participatns considered a vulnerable subject: pregnant women or fetuses, children, cognitively impaired adults, prisoners
- History of cannabis abuse or dependence
- History of coagulation abnormalities and thromboembolic disease or current abnormal coagulation test values
- History of stroke or acute coronary syndromes within 3 months before surgery
- Abnormal coagulation profile
- Renal failure (serum creatinine > 250?µmol/L [2.83?mg/dL]) or liver cirrhosis
- History of hypersensitivity to Percocet
- Participants on a pre-operative opioid management for any reason
- Current or a history of major psychiatric illness, such as bipolar disorder
- Current or a history of major depression, psychosis, or substance abuse disorder
- Current or a history of suicidal ideation
- Breastfeeding females
- Has clinically significant illness, including cardiovascular disorders
- With clinically significant lab abnormalities
- Has major neurological disorders, such as dementia, Parkinson’s disease, cognitive impairment, epilepsy, history of traumatic brain/head injury, or seizures
- Has moderate (Child-Pugh B) and severe hepatic impairment (Child-Pugh C).
If you are registered as a volunteer, please log in to contact the study team/express interest in this study.