The Effect of Tranexamic Acid on Calculated Total Blood Loss in Patients undergoing Revision Shoulder Arthroplasty

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Shoulder Pain
  • Age: Between 18 - 90 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Male or Female participants who are 18 years old or older
    2. Participants undergoing scheduled revision total shoulder arthroplasty
    3. Those who provide written informed consent and consent to be randomized

You may not be eligible for this study if the following are true:

    1. Pregnant or breast-feeding women
    2. Allergic to tranexamic acid
    3. Participants with proximal humerus fracture or fracture sequelae
    4. Participants who use estrogen containing medications
    5. Those who have acquired disturbances of color vision
    6. History of any of the following diagnosis
      • Subarachnoid hemorrhage
      • Active intravascular clotting
      • Severe pulmonary disease
      • Plasma creatinine > 115 µmol/L in males, > 100 µmol/L in females, or hepatic failure
      • Preoperative anemia
    7. Participants who refuse blood products
    8. Undergoing hormone replacement therapy
    9. Diagnosed or self-reported cognitive dysfunction
    10. Unable to understand or follow instructions
    11. Has severe liver disease, renal insufficiency, congestive heart failure, and/or significant heart disease
    12. Participants with BMI over 50
    13. Any participant that the investigators feel cannot comply with all study related procedures.



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