Synucleinopathy and Constipation: A Prospective Observational Study of the Physiology of Constipation in Comparison to Chronic Idiopathic Constipation

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Parkinson Disease
    Constipation, Multiple System Atrophy
  • Age: Between 18 - 100 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    1. Meet Rome IV criteria for functional constipation (below) OR use of laxative agents or stool softeners at least three times per week for the treatment of constipation
    2. Participants who meet two of the following:
      • Straining during at least 25% of defecations
      • Lumpy or hard stools in at least 25% of defecations
      • Sensation of incomplete evacuation for at least 25% of defecations
      • Sensation of anorectal obstruction/blockage for at least 25% of defecations
      • Manual maneuvers to facilitate at least 25% of defecations (such as digital evacuation, support of the pelvic floor)
      • Fewer than 3 defecations per week
    3. Participants who will provide written informed consent and will comply with scheduled visits and required study procedures

You may not be eligible for this study if the following are true:

    1. A history of gastric bezoars
    2. Swallowing disorders – inability to swallow capsule
    3. Suspected or known strictures, fistulas or physiological/mechanical GI obstruction
    4. Severe dysphagia to food or pills
    5. Crohn’s disease or diverticulitis
    6. Cardiac pacemakers or other implanted electromedical devices
    7. History of gastrointestinal surgery including bariatric surgery (gastric sleeve, roux en y gastric bypass)
    8. BMI >40 kg
    9. Has other serious neurological disorders
    10. Treatment with a dopamine receptor blocker or a dopamine-depleting agent in a dose and time-course consistent with drug-induced parkinsonism
    11. Pregnancy or lactation

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