Clinical Research Studies

This is an observational imaging study to evaluate the cardiac effects of weight loss in obese patients with a BMI >=30 with a confirmed diagnosis of hypertrophic cardiomyopathy. The sample size will be 120 patients. Based on the clinical evaluation of the NYU Langone Health Weight Management Program and on patient preference, patients will be offered either bariatric surgery or a diet and exercise regimen. Patient management before, during, and after weight loss intervention(s), including subsequent follow-up, will be in accordance to standard of care. Patients will have echocardiographic and quantitative radiographic imaging either by Cardiac MRI or ECG-Synchronized cardiac CT angiogram of the chest no more than 3 months before and again 18 months after their patient-chosen weight loss program. MRI is the preferred method of radiographic imaging while CT will be reserved only for patients who have a pacemaker or implanted cardiac defibrillator. Patients who do not complete their chosen weight loss program or those who do not lose weight by the End of Study visit will still undergo final research imaging procedures for comparison analysis.