Clinical Research Studies

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

• Conditions:
  Obesity
  Other Hypertrophic Cardiomyopathy
• Age: Between 18 Year(s) - 99 Year(s)
• Gender: Male or Female

• Other Inclusion Criteria:
  

  1. Those able to understand and comply with the stuy procedures,understand the risks involved in the study, and provide written informed consent
  2. Has accurate Transthoracic Echocardiogram (TTEs) that meet the following criteria:
     • Images are no more than 3 months prior to screening visit
     • The weight at the time of imaging cannot be +/- 4.5kg of current weight
     • If outside study images are used, they must be reviewed and deemed acceptable by the echocardiographer to obtain the measurements needed for the study
  3. Has adequate image quality from CMR or CT Scan at the time of screening and meet the following criteria:
     • Images are no more than 3 months prior to screening visit
     • The weight at the time of imaging cannot be +/- 4.5kg of current weight
     • If outside study images are used, they must be reviewed and deemed acceptable by the radiologist to obtain the measurements needed for the study
  4. Diagnosed with HCM
  5. Has BMI >= 30 at the time of screening
  6. Willing to participate in a weight loss program including diet and exercise or bariatric surgery

  
  

You may not be eligible for this study if the following are true:

• 1. Unable to comply with the study requirements, including the number of required visits to the clinical site
  2. Known infiltrative or storage disorder causing cardiac hypertrophy that mimics HCM, such as Fabry disease, amyloidosis, or Noonan syndrome with LV hypertrophy
  3. Pregnant
  4. Stage 3 or higher kidney disease
  5. Has any acute or serious comorbid condition that, in the judgment of the investigator, could pose a risk or interfere with the study participation
  6. Has safety laboratory parameters outside normal limits (chemistry)
  7. Has been successfully treated with invasive septal reduction
  8. Has a history or evidence of any other clinically significant disorder, condition, or disease that, in the opinion of the investigator, would pose a risk or interfere with the study participation
  9. For participants requiring CT scan instead of MRI, will be excluded if they have any contraindications to receiving Metoprolol or hypersensitive to any component of metoprolol