Gut microbiome alterations as a mechanism of immune dysregulation in new-onset refractory status epilepticus (NORSE)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

Conditions:
Status Epilepticus
Age: Between 6 - 100 Years
Gender: Male or Female

Other Inclusion Criteria:
NORSE subjects:
1. Male or female subjects, ages 6 to 100 years, with the diagnosis of new-onset refractory status epilepticus (NORSE):
  - without active epilepsy or other preexisting relevant neurological disorder
  - with viral infections and autoimmune syndromes of new onset, even if these are diagnosed in the initial 72 hours.
  - with remote brain injuries and with resolved epilepsy
FIRES subjects:
1. Male or female subjects, ages 6 to 100 years, with the diagnosis of febrile infection-related epilepsy syndrome (FIRES):
  - with fever starting between 2 weeks and 24 hours prior to the onset of refractory status epilepticus
  - with or without fever at the onset of status epilepticus.
Control subjects:
1. Male or female subjects, ages 6 to 100 years, diagnosed with status epilepticus of known cause, including but not limited to:
  - Structural
  - Metabolic
  - Infectious
  - Toxic
  - Genetic

You may not be eligible for this study if the following are true:

1. Participants who do not meet the inclusion criteria

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Clinical Research Studies