Gut microbiome alterations as a mechanism of immune dysregulation in new-onset refractory status epilepticus (NORSE)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    Status Epilepticus
  • Age: Between 6 - 100 Years
  • Gender: Male or Female
  • Other Inclusion Criteria:
    NORSE subjects:
    1. Male or female subjects, ages 6 to 100 years, with the diagnosis of new-onset refractory status epilepticus (NORSE):
      • without active epilepsy or other preexisting relevant neurological disorder
      • with viral infections and autoimmune syndromes of new onset, even if these are diagnosed in the initial 72 hours.
      • with remote brain injuries and with resolved epilepsy
    FIRES subjects:
    1. Male or female subjects, ages 6 to 100 years, with the diagnosis of febrile infection-related epilepsy syndrome (FIRES):
      • with fever starting between 2 weeks and 24 hours prior to the onset of refractory status epilepticus
      • with or without fever at the onset of status epilepticus.
    Control subjects:
    1. Male or female subjects, ages 6 to 100 years, diagnosed with status epilepticus of known cause, including but not limited to:
      • Structural
      • Metabolic
      • Infectious
      • Toxic
      • Genetic

You may not be eligible for this study if the following are true:

    1. Participants who do not meet the inclusion criteria



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