Gut Microbiome in Food Protein-Induced Enterocolitis Syndrome: An Observational Study

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Gut Microbiome in Food Protein-Induced Enterocolitis Syndrome: An Observational Study

Brief description of study

Food protein-induced enterocolitis syndrome (FPIES) is a non IgE-mediated food allergy that manifests with predominantly gastrointestinal symptoms and usually starts in the first year of life. There is no diagnostic biomarker and no treatment for FPIES beyond food avoidance, reflecting poorly understood pathophysiology. This is a prospective observational study, which will compare fecal microbiota, fecal short chain fatty acids and metabolomics between infants with FPIES and control infants and infants without food allergy, 0-12 months old. It will also compare mucosal immunity via epigenetic markers in blood in infants with FPIES, and infants with IgE-mediated food allergy. Stool samples will be collected from 50 infants with FPIES and 50 sex and age matched control infants birth through 12 months. Optional blood samples will be collected only from infants with FPIES and infants with IgE-mediated food allergies (0-12 months old). A questionnaire will be used to obtain information detailing the infant’s feeding, medical, birth, and family history.

Clinical Study Identifier: s20-01343

Principal Investigator: Anna H Nowak-Wegrzyn.

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