Gut Microbiome in Food Protein-Induced Enterocolitis Syndrome: An Observational Study

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions:
  • Age: Between 0 Month(s) - 12 Month(s)
  • Gender: Male or Female
  • Other Inclusion Criteria:
    FPIES subjects:
    1. History of a delayed repetitive vomiting and / or diarrhea within 1-4 hours without any other cause for the symptoms following the ingestion of the incriminated food or history of chronic diarrhea with mucous and / or blood, chronic vomiting, failure to thrive that resolved with the avoidance of the incriminated food
    2. Symptoms limited to the gastrointestinal tract
    3. Diagnosis of FPIES confirmed by physician
    Controls Infants with IgE-mediated food allergy:
    1. History of immediate (within 1-2 hours of food ingestion) convincing allergic symptoms such as hives, eczematous skin rashes, angioedema, rhinorrhea, hoarseness, cough, wheezing, anaphylaxis
    2. OR
    3. Evidence of IgE-sensitization to foods, documented as a positive skin prick test (wheal diameter >3 mm) and or detectable food-specific serum IgE >0.10 kIU/L
    4. AND
    5. Physician-diagnosed IgE-mediated food allergy
    Healthy infants:
    1. Thriving, without any atopic condition-no food allergy, no dietary restrictions, no eczema/atopic dermatitis, and no wheezing history

You may not be eligible for this study if the following are true:

    1. Treatment with oral antibiotics within the past 8 weeks for the infant and mother
    2. Supplementation with probiotics or with infant formula containing pre/probiotics within the past 8 weeks
    3. Supplementation with pre/probiotics within the past 8 weeks for infant’s mother
    4. Gestational age less than 37 weeks
    5. Diagnosis of a chronic disease
    6. Failure to thrive

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